Initiation of Anti-Hypertensive Drugs and Outcomes in Patients with Heart Failure with Reduced Ejection Fraction. (Record no. 974)

MARC details
000 -LEADER
fixed length control field 03456nam a22004457a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 220124s20212021 xxu||||| |||| 00| 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 0002-9343
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code 10.1016/j.amjmed.2021.11.012 [doi]
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code S0002-9343(21)00795-6 [pii]
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
PMID 34861194
245 ## - TITLE STATEMENT
Title Initiation of Anti-Hypertensive Drugs and Outcomes in Patients with Heart Failure with Reduced Ejection Fraction.
251 ## - Source
Source American Journal of Medicine. 2021 Nov 30
252 ## - Abbreviated Source
Abbreviated source Am J Med. 2021 Nov 30
253 ## - Journal Name
Journal name The American journal of medicine
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Year 2021
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Manufacturer FY2022
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Publication date 2021 Nov 30
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE]
Publication status aheadofprint
266 ## - Date added to catalog
Date added to catalog 2022-01-25
501 ## - WITH NOTE
Local holdings Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - present
520 ## - SUMMARY, ETC.
Abstract BACKGROUND: In patients with heart failure with reduced ejection fraction (HFrEF) and hypertension, systolic blood pressure is recommended to be maintained below 130 mmHg, although this has not been shown to be associated with improved outcomes. We examined the association of anti-hypertensive drug initiation and outcomes in patients with HFrEF.
520 ## - SUMMARY, ETC.
Abstract CONCLUSIONS: Among hospitalized older patients with HFrEF receiving contemporary treatments for heart failure, initiation of an anti-hypertensive drug was not associated with a lower risk of all-cause mortality or hospital readmission. Copyright (c) 2021. Published by Elsevier Inc.
520 ## - SUMMARY, ETC.
Abstract METHODS: In the Medicare-linked OPTIMIZE-HF, 7966 patients with HFrEF (ejection fraction <=40%) without renal failure were not receiving anti-hypertensive drugs before hospitalization, of whom 692 received discharge prescriptions for those drugs (thiazides and calcium channel blockers). We assembled a propensity score-matched cohort of 687 pairs of patients initiated and not initiated on anti-hypertensive drugs, balanced on 38 baseline characteristics. Hazard ratios (HR) and 95% confidence intervals (CI) for outcomes associated with anti-hypertensive drug initiation were estimated in matched cohort.
520 ## - SUMMARY, ETC.
Abstract RESULTS: Matched patients (n=1374) had a mean age of 74 years, 41% were women, 17% were African American, 66% were discharged on renin-angiotensin system inhibitors and beta blockers, and 10% on aldosterone antagonists. During 6 (median 2.5) years of follow-up, 70% of the patients died and 53% had heart failure readmission. Anti-hypertensive drug initiation was not significantly associated with all-cause mortality (HR, 0.95; 95% CI, 0.83-1.07) or heart failure readmission (HR, 0.93; 95% CI, 0.80-1.07). Similar associations were observed during 30 days and 12 months of follow-up.
546 ## - LANGUAGE NOTE
Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element IN PROCESS -- NOT YET INDEXED
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution MedStar Heart & Vascular Institute
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution MedStar Washington Hospital Center
656 ## - INDEX TERM--OCCUPATION
Department Internal Medicine Residency
656 ## - INDEX TERM--OCCUPATION
Department MedStar Georgetown University Hospital
657 ## - INDEX TERM--FUNCTION
Medline publication type Journal Article
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Allam, Shalini
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Lam, Phillip H
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Sheikh, Farooq
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Tsimploulis, Apostolos
790 ## - Authors
All authors Ahmed A, Allam SD, Allman RM, Aronow WS, Arundel C, Bhyan P, Deedwania P, Faselis C, Fonarow GC, Kanonidis IE, Lam PH, Patel S, Raman VK, Sheikh FH, Tsimploulis A
856 ## - ELECTRONIC LOCATION AND ACCESS
DOI <a href="https://dx.doi.org/10.1016/j.amjmed.2021.11.012">https://dx.doi.org/10.1016/j.amjmed.2021.11.012</a>
Public note https://dx.doi.org/10.1016/j.amjmed.2021.11.012
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Item type description Article
Holdings
Withdrawn status Lost status Damaged status Not for loan Collection Home library Current library Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
          MedStar Authors Catalog MedStar Authors Catalog 01/25/2022   34861194 34861194 01/25/2022 01/25/2022 Journal Article

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