MARC details
000 -LEADER |
fixed length control field |
03456nam a22004457a 4500 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
220124s20212021 xxu||||| |||| 00| 0 eng d |
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
International Standard Serial Number |
0002-9343 |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
10.1016/j.amjmed.2021.11.012 [doi] |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
S0002-9343(21)00795-6 [pii] |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
Ovid MEDLINE(R) |
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
PMID |
34861194 |
245 ## - TITLE STATEMENT |
Title |
Initiation of Anti-Hypertensive Drugs and Outcomes in Patients with Heart Failure with Reduced Ejection Fraction. |
251 ## - Source |
Source |
American Journal of Medicine. 2021 Nov 30 |
252 ## - Abbreviated Source |
Abbreviated source |
Am J Med. 2021 Nov 30 |
253 ## - Journal Name |
Journal name |
The American journal of medicine |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Year |
2021 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Manufacturer |
FY2022 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Publication date |
2021 Nov 30 |
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
Publication status |
aheadofprint |
266 ## - Date added to catalog |
Date added to catalog |
2022-01-25 |
501 ## - WITH NOTE |
Local holdings |
Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - present |
520 ## - SUMMARY, ETC. |
Abstract |
BACKGROUND: In patients with heart failure with reduced ejection fraction (HFrEF) and hypertension, systolic blood pressure is recommended to be maintained below 130 mmHg, although this has not been shown to be associated with improved outcomes. We examined the association of anti-hypertensive drug initiation and outcomes in patients with HFrEF. |
520 ## - SUMMARY, ETC. |
Abstract |
CONCLUSIONS: Among hospitalized older patients with HFrEF receiving contemporary treatments for heart failure, initiation of an anti-hypertensive drug was not associated with a lower risk of all-cause mortality or hospital readmission. Copyright (c) 2021. Published by Elsevier Inc. |
520 ## - SUMMARY, ETC. |
Abstract |
METHODS: In the Medicare-linked OPTIMIZE-HF, 7966 patients with HFrEF (ejection fraction <=40%) without renal failure were not receiving anti-hypertensive drugs before hospitalization, of whom 692 received discharge prescriptions for those drugs (thiazides and calcium channel blockers). We assembled a propensity score-matched cohort of 687 pairs of patients initiated and not initiated on anti-hypertensive drugs, balanced on 38 baseline characteristics. Hazard ratios (HR) and 95% confidence intervals (CI) for outcomes associated with anti-hypertensive drug initiation were estimated in matched cohort. |
520 ## - SUMMARY, ETC. |
Abstract |
RESULTS: Matched patients (n=1374) had a mean age of 74 years, 41% were women, 17% were African American, 66% were discharged on renin-angiotensin system inhibitors and beta blockers, and 10% on aldosterone antagonists. During 6 (median 2.5) years of follow-up, 70% of the patients died and 53% had heart failure readmission. Anti-hypertensive drug initiation was not significantly associated with all-cause mortality (HR, 0.95; 95% CI, 0.83-1.07) or heart failure readmission (HR, 0.93; 95% CI, 0.80-1.07). Similar associations were observed during 30 days and 12 months of follow-up. |
546 ## - LANGUAGE NOTE |
Language note |
English |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
Institution |
MedStar Heart & Vascular Institute |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
Institution |
MedStar Washington Hospital Center |
656 ## - INDEX TERM--OCCUPATION |
Department |
Internal Medicine Residency |
656 ## - INDEX TERM--OCCUPATION |
Department |
MedStar Georgetown University Hospital |
657 ## - INDEX TERM--FUNCTION |
Medline publication type |
Journal Article |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Allam, Shalini |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Lam, Phillip H |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Sheikh, Farooq |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Tsimploulis, Apostolos |
790 ## - Authors |
All authors |
Ahmed A, Allam SD, Allman RM, Aronow WS, Arundel C, Bhyan P, Deedwania P, Faselis C, Fonarow GC, Kanonidis IE, Lam PH, Patel S, Raman VK, Sheikh FH, Tsimploulis A |
856 ## - ELECTRONIC LOCATION AND ACCESS |
DOI |
<a href="https://dx.doi.org/10.1016/j.amjmed.2021.11.012">https://dx.doi.org/10.1016/j.amjmed.2021.11.012</a> |
Public note |
https://dx.doi.org/10.1016/j.amjmed.2021.11.012 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Koha item type |
Journal Article |
Item type description |
Article |