Recruiting Control Participants into Stroke Biomarker Studies. [Review]

MedStar author(s):
Citation: Translational Stroke Research. 11(5):861-870, 2020 10.PMID: 31912324Institution: MedStar Heart & Vascular Institute | MedStar National Rehabilitation NetworkForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: *Biomarkers/an [Analysis] | *Patient Care | *Research Design | *Stroke | Family | Humans | Spouses | Stroke/di [Diagnosis] | Stroke/dt [Drug Therapy]Year: 2020ISSN:
  • 1868-4483
Name of journal: Translational stroke researchAbstract: The number of scientists using -omics technologies to investigate biomarkers with the potential to gauge risk and aid in the diagnosis, treatment, and prognosis of stroke continues to rise, yet there are few resources to aid investigators in recruiting control participants. In this review, we describe two major strategies to match control participants to a stroke cohort-propensity score matching and one-to-one matching-including statistical approaches to gauge the balance between groups. We then explore the advantages and disadvantages of traditional recruitment methods including approaching spouses of enrolled stroke participants, direct recruitment from clinics, community outreach events, approaching retirement communities, and buying samples from a 3rd party vendor. Newer methods to identify controls by screening the electronic health record and using an online screening questionnaire are also described. Finally, we cover compensation for control participants and special considerations. The hope is that this review will serve as a roadmap whereby an investigator can successfully tailor their control recruitment strategy to the research question at hand and the local research environment. While this review is focused on blood-based biomarker studies, the principles will apply to investigators studying a broad range of biological materials.All authors: Edwardson MA, Fernandez SJOriginally published: Translational Stroke Research. 2020 Jan 08Fiscal year: FY2021Fiscal year of original publication: FY2020Digital Object Identifier: ORCID: Date added to catalog: 2020-01-31
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Journal Article MedStar Authors Catalog Article 31912324 Available 31912324

The number of scientists using -omics technologies to investigate biomarkers with the potential to gauge risk and aid in the diagnosis, treatment, and prognosis of stroke continues to rise, yet there are few resources to aid investigators in recruiting control participants. In this review, we describe two major strategies to match control participants to a stroke cohort-propensity score matching and one-to-one matching-including statistical approaches to gauge the balance between groups. We then explore the advantages and disadvantages of traditional recruitment methods including approaching spouses of enrolled stroke participants, direct recruitment from clinics, community outreach events, approaching retirement communities, and buying samples from a 3rd party vendor. Newer methods to identify controls by screening the electronic health record and using an online screening questionnaire are also described. Finally, we cover compensation for control participants and special considerations. The hope is that this review will serve as a roadmap whereby an investigator can successfully tailor their control recruitment strategy to the research question at hand and the local research environment. While this review is focused on blood-based biomarker studies, the principles will apply to investigators studying a broad range of biological materials.

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