MedStar Authors catalog › Details for: Intracranial hemorrhage in critically ill patients hospitalized for COVID-19.
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Intracranial hemorrhage in critically ill patients hospitalized for COVID-19.

by Fayed, Islam; Pivazyan, Gnel; Conte, Anthony G; Chang, Jason; Mai, Jeffrey C.
Citation: Journal of Clinical Neuroscience. 81:192-195, 2020 Nov..Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia.Published: ; 2020ISSN: 0967-5868.Full author list: Fayed I; Pivazyan G; Conte AG; Chang J; Mai JC.UI/PMID: 33222915.Subject(s): Aged | *COVID-19/co [Complications] | *Cerebral Hemorrhage/vi [Virology] | Critical Illness | Female | Hospitalization | Humans | Male | Middle Aged | SARS-CoV-2Institution(s): MedStar Washington Hospital CenterDepartment(s): Neurosurgery | Surgical Critical CareActivity type: Journal Article.Medline article type(s): Case Reports | Journal ArticleDigital Object Identifier: https://dx.doi.org/10.1016/j.jocn.2020.08.026 (Click here) Abbreviated citation: J Clin Neurosci. 81:192-195, 2020 Nov.Abstract: In this study, we report three cases of spontaneous intracranial hemorrhage in patients who were initially hospitalized at our tertiary care center in Washington, DC with symptoms of COVID-19. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was diagnosed in all three patients, who were critically ill, requiring intubation and ventilatory support. During their protracted hospitalizations, subsequent imaging disclosed intracranial hemorrhages, including intracerebral and subarachnoid hemorrhages, in the context of anticoagulation and coagulopathy. We believe this is related to the tropism of SARS-CoV-2 to the endothelial lining of the cerebral vasculature via their angiotensin-converting enzyme (ACE) II receptors. Given our findings, we advocate heightened vigilance for intracerebral hemorrhage events, and scanning when practicable, in COVID-19 patients which have prolonged ventilatory support and depressed neurologic examinations. Copyright (c) 2020. Published by Elsevier Ltd.

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