Abnormalities in the white matter tracts in patients with Parkinson disease and psychosis.
Citation: Neurology. 94(18):e1876-e1884, 2020 05 05.PMID: 32317347Institution: MedStar Washington Hospital CenterDepartment: NeurologyForm of publication: Journal ArticleMedline article type(s): Comment | Journal ArticleSubject headings: *Brain/pa [Pathology] | *Parkinson Disease/pa [Pathology] | *Psychotic Disorders/pa [Pathology] | *White Matter/pa [Pathology] | Aged | Cross-Sectional Studies | Diffusion Tensor Imaging | Female | Humans | Male | Middle Aged | Parkinson Disease/co [Complications] | Psychotic Disorders/et [Etiology]Year: 2020Local holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006ISSN:- 0028-3878
- Lenka, Abhishek:
- http://orcid.org/0000-0003-0725-636X
Item type | Current library | Collection | Call number | Status | Date due | Barcode |
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Journal Article | MedStar Authors Catalog | Article | 32317347 | Available | 32317347 |
Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006
CONCLUSION: This study provides novel insights into the putative role of WM tract abnormalities in the pathogenesis of PD-P by demonstrating significant alterations in several WM tracts. Additional longitudinal studies are warranted to confirm the findings of our research. Copyright (c) 2020 American Academy of Neurology.
METHODS: This cross-sectional study involved 48 PD-NP and 42 PD-P who were matched for age, sex, and education. Tract-based spatial statistics (TBSS) was used to compare several DTI metrics from the diffusion-weighted MRIs obtained through a 3-Tesla scanner. A set of neuropsychological tests was used for the cognitive evaluation of all patients.
OBJECTIVE: The objective of the current study was to compare the microstructural integrity of the white matter (WM) tracts in patients having Parkinson disease (PD) with and without psychosis (PD-P and PD-NP) through diffusion tensor imaging (DTI).
RESULTS: The severity and stage of PD were not statistically different between the groups. The PD-P group performed poorly in all the neuropsychological domains compared with the PD-NP group. TBSS analysis revealed widespread patterns of abnormality in the fractional anisotropy (FA) in the PD-P group, which also correlated with some of the cognitive scores. These tracts include inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, right parieto-occipital WM, body of the corpus callosum, and corticospinal tract.
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