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Management of post-transplant lymphoproliferative disorders. [Review]

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Citation: British Journal of Haematology. 182(3):330-343, 2018 08.PMID: 29741774Institution: Washington Cancer InstituteForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: *Lymphoproliferative Disorders/et [Etiology] | *Organ Transplantation/ae [Adverse Effects] | Epstein-Barr Virus Infections/co [Complications] | Humans | Immunocompromised Host | Immunosuppressive Agents/ae [Adverse Effects] | Lymphoproliferative Disorders/di [Diagnosis] | Lymphoproliferative Disorders/im [Immunology] | Lymphoproliferative Disorders/th [Therapy] | Prognosis | Risk FactorsYear: 2018 Local holdings: Available online through MWHC library: 1995 - 2013ISSN:

0007-1048

Name of journal: British journal of haematologyAbstract: Copyright (c) 2018 John Wiley & Sons Ltd.The post-transplant lymphoproliferative disorders (PTLDs) are a heterogeneous group of neoplasms that are one of the most serious complications of bone marrow and solid organ transplants. Because these disorders are rare, there are no randomized trials from which to derive optimal treatment. Management can be challenging and must balance the goal of PTLD eradication with the risks of graft rejection, graft-versus-host disease, further delays in immune reconstitution and life-threatening infections, among others. This paper will provide a comprehensive review of PTLD following solid organ transplant and haematopoietic stem cell transplant with a focus on management. Included is a discussion of novel agents that are being studied in clinical trials and, when combined or sequenced with conventional therapy, have the potential to improve outcomes.All authors: Catlett JP, Desai SH, DeStefano CB, Shenoy AGFiscal year: FY2018Fiscal year of original publication: FY2018Digital Object Identifier:

https://dx.doi.org/10.1111/bjh.15263

ORCID:

http://orcid.org/0000-0002-8890-7760

Date added to catalog: 2018-06-19

Holdings ( 1 )
Title notes ( 4 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	29741774	Available		29741774

Available online through MWHC library: 1995 - 2013

The post-transplant lymphoproliferative disorders (PTLDs) are a heterogeneous group of neoplasms that are one of the most serious complications of bone marrow and solid organ transplants. Because these disorders are rare, there are no randomized trials from which to derive optimal treatment. Management can be challenging and must balance the goal of PTLD eradication with the risks of graft rejection, graft-versus-host disease, further delays in immune reconstitution and life-threatening infections, among others. This paper will provide a comprehensive review of PTLD following solid organ transplant and haematopoietic stem cell transplant with a focus on management. Included is a discussion of novel agents that are being studied in clinical trials and, when combined or sequenced with conventional therapy, have the potential to improve outcomes.

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