Poor patient compliance with instructions for continuous sialogogues after <sup>131</sup> I therapy.

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Citation: Oral Diseases. 25(1):158-163, 2019 Jan.PMID: 30169900Institution: MedStar Washington Hospital CenterDepartment: Medicine/Endocrinology | Medicine/Nuclear MedicineForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Medication Adherence | *Salivation/de [Drug Effects] | *Sialadenitis/dt [Drug Therapy] | *Thyroid Neoplasms/rt [Radiotherapy] | *Xerostomia/dt [Drug Therapy] | Adult | Aged | Female | Humans | Iodine Radioisotopes/tu [Therapeutic Use] | Male | Middle Aged | Prospective Studies | Sialadenitis/et [Etiology] | Surveys and Questionnaires | Thyroid Neoplasms/co [Complications] | Xerostomia/et [Etiology]Year: 2019ISSN:
  • 1354-523X
Name of journal: Oral diseasesAbstract: CONCLUSION: Despite repetitive instructions to use sialogogues continuously, most patients (90%) were not compliant. In future studies, strict monitoring and evaluation of patient compliance will be crucial when assessing the effect of continuous versus intermittent or delayed initiation of sialogogues.Copyright (c) 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.METHODS: Differentiated thyroid cancer patients who were clinically scheduled for an <sup>131</sup> I therapy at MedStar Washington Hospital Center between 2012 and 2013 were given instructions for continuous sialogogues per standard clinical protocol. The prospective survey was given at multiple time points.OBJECTIVES: To analyze the role of patient compliance as a factor in evaluating the effectiveness of continuous sialogogues to prevent salivary side effects from <sup>131</sup> I therapy in differentiated thyroid cancer patients.RESULTS: Ninety-nine patients consented to participate of whom 94 participants had complete data. The mean prescribed <sup>131</sup> I activity was 121 +/- 50 mCi (4.5 +/- 1.9 GBq), range 27.5-288 mCi (1.0-10.7 GBq ). Overall, only 10% (9/94) of patients were compliant with continuous sialogogues. Even though all patients took sialogogues on the first day of post-therapy, 17% of participants did not continuously take sialogogues during the first day, 60% during the first night, and 72% on the second day despite rigorous instructions to continue for two days.All authors: Burman KD, Kharazi P, Khorjekar G, Kulkarni K, Moreau S, Van Nostrand D, Wartofsky L, Wu DFiscal year: FY2019Digital Object Identifier: ORCID: Date added to catalog: 2018-09-28
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Journal Article MedStar Authors Catalog Article 30169900 Available 30169900

CONCLUSION: Despite repetitive instructions to use sialogogues continuously, most patients (90%) were not compliant. In future studies, strict monitoring and evaluation of patient compliance will be crucial when assessing the effect of continuous versus intermittent or delayed initiation of sialogogues.

Copyright (c) 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.

METHODS: Differentiated thyroid cancer patients who were clinically scheduled for an <sup>131</sup> I therapy at MedStar Washington Hospital Center between 2012 and 2013 were given instructions for continuous sialogogues per standard clinical protocol. The prospective survey was given at multiple time points.

OBJECTIVES: To analyze the role of patient compliance as a factor in evaluating the effectiveness of continuous sialogogues to prevent salivary side effects from <sup>131</sup> I therapy in differentiated thyroid cancer patients.

RESULTS: Ninety-nine patients consented to participate of whom 94 participants had complete data. The mean prescribed <sup>131</sup> I activity was 121 +/- 50 mCi (4.5 +/- 1.9 GBq), range 27.5-288 mCi (1.0-10.7 GBq ). Overall, only 10% (9/94) of patients were compliant with continuous sialogogues. Even though all patients took sialogogues on the first day of post-therapy, 17% of participants did not continuously take sialogogues during the first day, 60% during the first night, and 72% on the second day despite rigorous instructions to continue for two days.

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