Citation: Case Reports in Gastrointestinal Medicine. 2021:5555961, 2021..Journal: Case reports in gastrointestinal medicine.Published: ; 2021Full author list: Del Castillo JRF; Yousaf MN; Chaudhary FS; Saleh N; Mills L.UI/PMID: 33791134.Subject(s): IN PROCESS -- NOT YET INDEXEDInstitution(s): MedStar Union Memorial Hospital | MedStar Good Samaritan HospitalDepartment(s): Internal Medicine ResidencyActivity type: Journal Article.Medline article type(s): Case ReportsDigital Object Identifier: https://dx.doi.org/10.1155/2021/5555961xl - https://dx.doi.org/10.1155/2021/5555961 (Click here)ORCID: Del Castillo, Jennifer Rose F https://orcid.org/0000-0001-7945-2197Yousaf, Muhammad Nadeem https://orcid.org/0000-0002-7979-8929Chaudhary, Fizah S https://orcid.org/0000-0001-6458-5755Saleh, Nahar https://orcid.org/0000-0001-5454-6824 (Click here) | (Click here) | (Click here) | (Click here)Abbreviated citation: Case Rep Gastrointest Med. 2021:5555961, 2021.Abstract: Pemphigus vulgaris (PV) is an autoimmune blistering disorder of the skin and mucosal surfaces characterized by acantholysis (loss of adhesion between epidermal cells). Esophageal involvement of PV is an underdiagnosed entity as routine diagnostic endoscopy is not recommended in asymptomatic patients. Dysphagia and odynophagia are common presenting symptoms; however, upper gastrointestinal bleeding (UGIB) associated with esophageal involvement of PV without a history of mucosal blistering is extremely uncommon. We present a case of esophageal involvement of PV associated with active UGIB that was diagnosed on endoscopic evaluation. This case illustrated the importance of early endoscopy to identify the esophageal involvement of PV especially in patients with preexisting disease who present with gastrointestinal symptoms such as dysphagia, odynophagia, and hematemesis. Early recognition of esophageal involvement of PV and initiation of corticosteroid and/or immunosuppressant therapy may improve the outcome of the disease. Copyright (c) 2021 Jennifer Rose F. Del Castillo et al.