Topical sirolimus for treatment of a venolymphatic malformation in an adolescent girl.

MedStar author(s):
Citation: Pediatric Dermatology. 35(6):e406-e407, 2018 Nov.PMID: 30152558Institution: MedStar Washington Hospital CenterDepartment: DermatologyForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Immunosuppressive Agents/ad [Administration & Dosage] | *Sirolimus/ad [Administration & Dosage] | *Vascular Malformations/dt [Drug Therapy] | Administration, Topical | Adolescent | Female | Humans | Treatment OutcomeYear: 2018ISSN:
  • 0736-8046
Name of journal: Pediatric dermatologyAbstract: Copyright (c) 2018 Wiley Periodicals, Inc.Sirolimus has emerged as a promising treatment for complex congenital vascular malformations but is limited because of systemic side effects. Topically compounded formulations, which have been found to be successful in the treatment of several other conditions, are a preferred drug delivery system to provide local therapy. We report a case of a venolymphatic malformation in an adolescent girl treated with topical 1% sirolimus cream leading to improvement in appearance and associated symptoms.All authors: Cardis MA, DeKlotz CMCFiscal year: FY2019Digital Object Identifier: ORCID: Date added to catalog: 2018-08-31
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Journal Article MedStar Authors Catalog Article 30152558 Available 30152558

Copyright (c) 2018 Wiley Periodicals, Inc.

Sirolimus has emerged as a promising treatment for complex congenital vascular malformations but is limited because of systemic side effects. Topically compounded formulations, which have been found to be successful in the treatment of several other conditions, are a preferred drug delivery system to provide local therapy. We report a case of a venolymphatic malformation in an adolescent girl treated with topical 1% sirolimus cream leading to improvement in appearance and associated symptoms.

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