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Thyrotropin isoforms: implications for thyrotropin analysis and clinical practice. [Review]

MedStar author(s):

Citation: Thyroid. 24(3):411-23, 2014 Mar.PMID: 24073798Institution: MedStar Washington Hospital CenterDepartment: Medicine/EndocrinologyForm of publication: Journal ArticleMedline article type(s): Journal Article | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | ReviewSubject headings: *Hypothyroidism/di [Diagnosis] | *Thyroid Function Tests | *Thyrotropin/an [Analysis] | Humans | Hypothyroidism/bl [Blood] | Immunoassay | Protein Isoforms | Thyrotropin/bl [Blood]Year: 2014 Local holdings: Available online from MWHC library: August 2000 - present, Available in print through MWHC library: 1999 - 2006ISSN:

1050-7256

Name of journal: Thyroid : official journal of the American Thyroid AssociationAbstract: Serum thyrotropin (TSH) is considered the single most sensitive and specific measure of thyroid function in the general population owing to its negative logarithmic association with free triiodothyronine and free thyroxine concentrations. It is therefore often the test of choice for screening, diagnosis, and monitoring of primary hypothyroidism. Serum TSH concentrations can be analyzed quantitatively using third-generation immunoassays, whereas its bioactivity can be measured by TSH activity assays in cell culture. Theoretically, if serum TSH concentrations are directly related to TSH activity, the two tests should yield comparable results. However, on occasion, the results are discordant, with serum concentrations being higher than TSH biological activity. This review focuses on the dissociation between the clinical state and serum TSH concentrations and addresses clinically important aspects of TSH analysis.All authors: Buckey TM, Burman KD, Estrada JM, Soldin D, Soldin OPFiscal year: FY2014Digital Object Identifier:

http://dx.doi.org/10.1089/thy.2013.0119

Date added to catalog: 2014-11-25

Holdings ( 1 )
Title notes ( 3 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	24073798	Available		24073798

Available online from MWHC library: August 2000 - present, Available in print through MWHC library: 1999 - 2006

Serum thyrotropin (TSH) is considered the single most sensitive and specific measure of thyroid function in the general population owing to its negative logarithmic association with free triiodothyronine and free thyroxine concentrations. It is therefore often the test of choice for screening, diagnosis, and monitoring of primary hypothyroidism. Serum TSH concentrations can be analyzed quantitatively using third-generation immunoassays, whereas its bioactivity can be measured by TSH activity assays in cell culture. Theoretically, if serum TSH concentrations are directly related to TSH activity, the two tests should yield comparable results. However, on occasion, the results are discordant, with serum concentrations being higher than TSH biological activity. This review focuses on the dissociation between the clinical state and serum TSH concentrations and addresses clinically important aspects of TSH analysis.

English