Evidence Regarding Pharmacogenetics in Pain Management and Cancer.

MedStar author(s):
Citation: Oncologist. 2023 Jan 30PMID: 36718020Department: MedStar Health | PharmacogenomicsForm of publication: Journal ArticleMedline article type(s): Comment | EditorialSubject headings: IN PROCESS -- NOT YET INDEXEDYear: 2023ISSN:
  • 1083-7159
Name of journal: The oncologistAbstract: Patients experience interindividual variation in response to analgesics, which may be partially explained by genetics. This commentary discusses a recently published trial on COMT genotype and opioid dose requirements and describes the potential role for COMT and other genes (eg, CYP2D6) on opioid therapy and the current evidence for germline pharmacogenetics and resources for opioid pharmacogenetics. Copyright © The Author(s) 2023. Published by Oxford University Press.All authors: Smith DMFiscal year: FY2023Digital Object Identifier:
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Journal Article MedStar Authors Catalog Article 36718020 Available 36718020

Patients experience interindividual variation in response to analgesics, which may be partially explained by genetics. This commentary discusses a recently published trial on COMT genotype and opioid dose requirements and describes the potential role for COMT and other genes (eg, CYP2D6) on opioid therapy and the current evidence for germline pharmacogenetics and resources for opioid pharmacogenetics. Copyright © The Author(s) 2023. Published by Oxford University Press.

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