MedStar Authors catalog › Details for: First in-human evaluation of a novel intravascular ultrasound and optical coherence tomography system for intracoronary imaging.
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First in-human evaluation of a novel intravascular ultrasound and optical coherence tomography system for intracoronary imaging.

by Dan, Kazuhiro; Garcia-Garcia, Hector M; Kuku, Kayode.
Citation: Catheterization & Cardiovascular Interventions. 99(3):686-698, 2022 02.; .Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.Published: 2022; ; ; ; ISSN: 1522-1946.Full author list: Akl E; Courtney BK; Dan K; Garcia-Garcia HM; Kuku KO; Mehta SR; Pinilla-Echeverri N; Sheth T.UI/PMID: 34792273.Subject(s): *Coronary Artery Disease | *Percutaneous Coronary Intervention | Coronary Artery Disease/dg [Diagnostic Imaging] | Coronary Artery Disease/th [Therapy] | Coronary Vessels/dg [Diagnostic Imaging] | Humans | Percutaneous Coronary Intervention/ae [Adverse Effects] | Percutaneous Coronary Intervention/mt [Methods] | Predictive Value of Tests | Stents | Tomography, Optical Coherence | Treatment Outcome | Ultrasonography, Interventional/mt [Methods]Institution(s): MedStar Heart & Vascular InstituteActivity type: Journal Article.Medline article type(s): Journal ArticleDigital Object Identifier: (Click here) ORCID: Dan, Kazuhiro (Click here) Abbreviated citation: Catheter Cardiovasc Interv. 99(3):686-698, 2022 02; .Local Holdings: Available online from MWHC library: 1996 - present, Available in print through MWHC library: 1996 - 2006.Abstract: AIMS: We evaluated the first in-human performance of a novel hybrid imaging catheter that permits simultaneous and co-registered acquisition of intravascular ultrasound (IVUS) and optical coherence tomography (OCT) images.Abstract: CONCLUSIONS: Hybrid image acquisition was safe. The availability of both IVUS and OCT changed image interpretation compared to either modality alone, suggesting a complementary role of these two techniques. Copyright (c) 2021 Wiley Periodicals LLC.Abstract: METHODS AND RESULTS: A total of 17 patients undergoing planned percutaneous coronary intervention (PCI) were imaged between August 2018 and August 2019. Eleven patients with both pre- and post-PCI IVUS and OCT images were included in the offline image analysis. IVUS and OCT images were analyzed separately then together with co-registered images for pre-stent findings, and only separately for post-stent findings. A total of 926 frames were analyzed (218 pre-PCI, 708 post-PCI). There was substantial agreement to detect calcific plaque between co-registered IVUS-OCT and standalone IVUS (Kappa 0.72 [0.65-0.79]) and standalone OCT (Kappa 0.75 [0.68-0.81]) while standalone imaging modalities showed lower agreement to detect lipidic and fibrotic plaques compared with co-registered IVUS-OCT. There were more frames with stent underexpansion on IVUS than OCT [72 (28.7%) vs. 58 (23.1%), respectively, p = 0.039]. Detection rates of incomplete stent apposition (present on 20 OCT frames vs. 2 IVUS frames, p < 0.001) and tissue protrusion (40 vs. 27 frames, p < 0.001) were higher on OCT than IVUS. One stent edge dissection was detected in the image analysis and was seen on OCT but not IVUS. All 177 frames with image artifacts contained at least one co-registered imaging modality with interpretable diagnostic content. There were no study device-related adverse events.

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