Obesity in adult lymphoma survivors.

MedStar author(s):
Citation: Leukemia & Lymphoma. 53(4):569-74, 2012 Apr.PMID: 21888618Institution: MedStar Health Research Institute | Washington Cancer InstituteForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Lymphoma/pp [Physiopathology] | *Obesity/pp [Physiopathology] | *Survivors | *Weight Gain/ph [Physiology] | Adult | Age Factors | Aged | Aged, 80 and over | Body Mass Index | Body Weight/de [Drug Effects] | Body Weight/ph [Physiology] | Body Weight/re [Radiation Effects] | Chemoradiotherapy | Female | Humans | Logistic Models | Lymphoma/dt [Drug Therapy] | Lymphoma/rt [Radiotherapy] | Male | Middle Aged | Retrospective Studies | Risk Factors | Sex Factors | Time Factors | Weight Gain/de [Drug Effects] | Weight Gain/re [Radiation Effects] | Young AdultISSN:
  • 1026-8022
Name of journal: Leukemia & lymphomaAbstract: As a result of therapeutic advances, survivors of lymphoma are now living longer. However, their mortality is higher when compared to the general population, probably due to multiple factors. Survivors of childhood leukemia and lymphoma appear to have an increased prevalence of obesity. The objectives of this retrospective study were to analyze weight 130912 after lymphoma treatment in an adult population and determine factors predictive of weight gain. Data were collected from 219 patients and analyzed sequentially at the initial visit and at 6, 12 and 18 months. There was a progressive increase in weight from the initial visit to 6 months (1.5% increase of initial body weight), 12 months (4.5%) and 18 months (6.4%). More than 9% of patients experienced weight gain greater than 20% during follow-up. There was a statistically significant association between the percentage of increase in weight and age, B symptoms and body mass index (BMI) at presentation. Younger patients, those with B symptoms or those with lower BMI manifested more weight gain (p = 0.0008, p = 0.0440 and p = 0.0009, respectively). Other assessed factors had no effect on weight gain including sex, race, lymphoma histology, disease outcome, radiation therapy, number of treatment regimens and use of steroids. Further studies are needed to explore long-term weight trends and their impact on the health of lymphoma survivors.All authors: Catlett J, Lynce F, Malkovska V, Pehlivanova MDigital Object Identifier: Date added to catalog: 2013-09-17
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Journal Article MedStar Authors Catalog Article Available 21888618

As a result of therapeutic advances, survivors of lymphoma are now living longer. However, their mortality is higher when compared to the general population, probably due to multiple factors. Survivors of childhood leukemia and lymphoma appear to have an increased prevalence of obesity. The objectives of this retrospective study were to analyze weight 130912 after lymphoma treatment in an adult population and determine factors predictive of weight gain. Data were collected from 219 patients and analyzed sequentially at the initial visit and at 6, 12 and 18 months. There was a progressive increase in weight from the initial visit to 6 months (1.5% increase of initial body weight), 12 months (4.5%) and 18 months (6.4%). More than 9% of patients experienced weight gain greater than 20% during follow-up. There was a statistically significant association between the percentage of increase in weight and age, B symptoms and body mass index (BMI) at presentation. Younger patients, those with B symptoms or those with lower BMI manifested more weight gain (p = 0.0008, p = 0.0440 and p = 0.0009, respectively). Other assessed factors had no effect on weight gain including sex, race, lymphoma histology, disease outcome, radiation therapy, number of treatment regimens and use of steroids. Further studies are needed to explore long-term weight trends and their impact on the health of lymphoma survivors.

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