Normal view MARC view ISBD view

Axial (spinal) gout. [Review]

MedStar author(s):

Citation: Current Rheumatology Reports. 14(2):161-4, 2012 Apr.PMID: 22318623Institution: MedStar Washington Hospital CenterDepartment: Medicine/RheumatologyForm of publication: Journal ArticleMedline article type(s): Journal Article | Research Support, Non-U.S. Gov't | ReviewSubject headings: *Arthritis, Gouty/di [Diagnosis] | *Gout/di [Diagnosis] | *Hyperuricemia/di [Diagnosis] | *Spinal Diseases/di [Diagnosis] | Arthritis, Gouty/pp [Physiopathology] | Gout/pp [Physiopathology] | Humans | Hyperuricemia/pp [Physiopathology] | Spinal Diseases/pp [Physiopathology]ISSN:

1523-3774

Name of journal: Current rheumatology reportsAbstract: Gout is a common metabolic disorder resulting from supersaturation of uric acid in extracellular fluid and deposition of monosodium urate crystals in tissues. Gouty arthritis typically affects the peripheral joints of the appendicular skeleton, especially the feet and hands. Gouty involvement of the spine, however, is not as rare as generally perceived. Although it may be asymptomatic, tophaceous axial gout is also a well-documented cause of acute back pain, radiculopathy, and frank cord compression. As with the appendicular skeleton, it takes several years of gout before radiological evidence of erosive change or tophi is apparent in the axial skeleton. This is best detected by CT imaging. The sequelae of cord compression can be reversed with timely surgical intervention and maintenance of uric acid-lowering therapy. The long-term effects of urate-lowering therapies on axial gout have not been studied.All authors: Konatalapalli R, Lumezanu E, Weinstein ADigital Object Identifier:

http://dx.doi.org/10.1007/s11926-012-0236-8

Date added to catalog: 2013-09-17

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Title notes ( 2 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article		Available		22318623

Gout is a common metabolic disorder resulting from supersaturation of uric acid in extracellular fluid and deposition of monosodium urate crystals in tissues. Gouty arthritis typically affects the peripheral joints of the appendicular skeleton, especially the feet and hands. Gouty involvement of the spine, however, is not as rare as generally perceived. Although it may be asymptomatic, tophaceous axial gout is also a well-documented cause of acute back pain, radiculopathy, and frank cord compression. As with the appendicular skeleton, it takes several years of gout before radiological evidence of erosive change or tophi is apparent in the axial skeleton. This is best detected by CT imaging. The sequelae of cord compression can be reversed with timely surgical intervention and maintenance of uric acid-lowering therapy. The long-term effects of urate-lowering therapies on axial gout have not been studied.

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