Out-of-plane Stokes imaging polarimeter for early skin cancer diagnosis.

MedStar author(s):
Citation: Journal of Biomedical Optics. 17(7):076014, 2012 Jul.PMID: 22894497Institution: MedStar Washington Hospital Center | Washington Cancer InstituteDepartment: Surgery/Burn ServicesForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Scanning Laser Polarimetry/is [Instrumentation] | *Scanning Laser Polarimetry/mt [Methods] | *Skin Neoplasms/pa [Pathology] | *Spectrum Analysis, Raman/is [Instrumentation] | *Spectrum Analysis, Raman/mt [Methods] | Early Diagnosis | Equipment Design | Equipment Failure Analysis | Humans | Reproducibility of Results | Sensitivity and SpecificityISSN:
  • 1083-3668
Name of journal: Journal of biomedical opticsAbstract: Optimal treatment of skin cancer before it metastasizes critically depends on early diagnosis and treatment. Imaging spectroscopy and polarized remittance have been utilized in the past for diagnostic purposes, but valuable information can be also obtained from the analysis of skin roughness. For this purpose, we have developed an out-of-plane hemispherical Stokes imaging polarimeter designed to monitor potential skin neoplasia based on a roughness assessment of the epidermis. The system was utilized to study the rough surface scattering for wax samples and human skin. The scattering by rough skin-simulating phantoms showed behavior that is reasonably described by a facet scattering model. Clinical tests were conducted on patients grouped as follows: benign nevi, melanocytic nevus, melanoma, and normal skin. Images were captured and analyzed, and polarization properties are presented in terms of the principal angle of the polarization ellipse and the degree of polarization. In the former case, there is separation between different groups of patients for some incidence azimuth angles. In the latter, separation between different skin samples for various incidence azimuth angles is observed.All authors: Boisvert ME, Flanagan KE, Germer TA, Ghassemi P, Jordan MH, Lemaillet P, Ramella-Roman JC, Shupp JW, Venna SSDigital Object Identifier: Date added to catalog: 2013-09-17
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Journal Article MedStar Authors Catalog Article Available 22894497

Optimal treatment of skin cancer before it metastasizes critically depends on early diagnosis and treatment. Imaging spectroscopy and polarized remittance have been utilized in the past for diagnostic purposes, but valuable information can be also obtained from the analysis of skin roughness. For this purpose, we have developed an out-of-plane hemispherical Stokes imaging polarimeter designed to monitor potential skin neoplasia based on a roughness assessment of the epidermis. The system was utilized to study the rough surface scattering for wax samples and human skin. The scattering by rough skin-simulating phantoms showed behavior that is reasonably described by a facet scattering model. Clinical tests were conducted on patients grouped as follows: benign nevi, melanocytic nevus, melanoma, and normal skin. Images were captured and analyzed, and polarization properties are presented in terms of the principal angle of the polarization ellipse and the degree of polarization. In the former case, there is separation between different groups of patients for some incidence azimuth angles. In the latter, separation between different skin samples for various incidence azimuth angles is observed.

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