MedStar Authors catalog › Details for: Trastuzumab plus adjuvant chemotherapy for human epidermal growth factor receptor 2-positive breast cancer: planned joint analysis of overall survival from NSABP B-31 and NCCTG N9831.
Normal view MARC view ISBD view

Trastuzumab plus adjuvant chemotherapy for human epidermal growth factor receptor 2-positive breast cancer: planned joint analysis of overall survival from NSABP B-31 and NCCTG N9831.

by Swain, Sandra M.
Citation: Journal of Clinical Oncology. 32(33):3744-52, 2014 Nov 20..Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology.ISSN: 0732-183X.Full author list: Perez EA; Romond EH; Suman VJ; Jeong JH; Sledge G; Geyer CE Jr; Martino S; Rastogi P; Gralow J; Swain SM; Winer EP; Colon-Otero G; Davidson NE; Mamounas E; Zujewski JA; Wolmark N.UI/PMID: 25332249.Subject(s): Adolescent | Adult | Aged | *Antibodies, Monoclonal, Humanized/ad [Administration & Dosage] | *Antineoplastic Combined Chemotherapy Protocols/tu [Therapeutic Use] | Breast Neoplasms/ch [Chemistry] | *Breast Neoplasms/dt [Drug Therapy] | Breast Neoplasms/mo [Mortality] | Chemotherapy, Adjuvant | Disease-Free Survival | Female | Humans | Middle Aged | *Receptor, ErbB-2/an [Analysis]Institution(s): Washington Cancer InstituteActivity type: Journal Article.Medline article type(s): Journal Article | Randomized Controlled Trial | Research Support, Non-U.S. Gov'tOnline resources: Click here to access online Digital Object Identifier: http://dx.doi.org/10.1200/JCO.2014.55.5730 (Click here) Abbreviated citation: J Clin Oncol. 32(33):3744-52, 2014 Nov 20.Local Holdings: Available online from MWHC library: 1999 - present, Available in print through MWHC library: 1999 - 2008.Abstract: PURPOSE: Positive interim analysis findings from four large adjuvant trials evaluating trastuzumab in patients with early-stage human epidermal growth factor receptor 2 (HER2) -positive breast cancer were first reported in 2005. One of these reports, the joint analysis of North Central Cancer Treatment Group NCCTG N9831 (Combination Chemotherapy With or Without Trastuzumab in Treating Women With HER2-Overexpressing Breast Cancer) and the National Surgical Adjuvant Breast and Bowel Project NSABP B-31 (Doxorubicin and Cyclophosphamide Plus Paclitaxel With or Without Trastuzumab in Treating Women With Node-Positive Breast Cancer That Overexpresses HER2), was updated in 2011. We now report the planned definitive overall survival (OS) results from this joint analysis along with updates on the disease-free survival (DFS) end point.Abstract: METHODS: In all, 4,046 patients with HER2-positive operable breast cancer were enrolled to receive doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in both trials. The required number of events for the definitive statistical analysis for OS (710 events) was reached in September 2012. Updated analyses of overall DFS and related subgroups were also performed.Abstract: RESULTS: Median time on study was 8.4 years. Adding trastuzumab to chemotherapy led to a 37% relative improvement in OS (hazard ratio [HR], 0.63; 95% CI, 0.54 to 0.73; P < .001) and an increase in 10-year OS rate from 75.2% to 84%. These results were accompanied by an improvement in DFS of 40% (HR, 0.60; 95% CI, 0.53 to 0.68; P < .001) and increase in 10-year DFS rate from 62.2% to 73.7%. All patient subgroups benefited from addition of this targeted anti-HER2 agent.Abstract: CONCLUSION: The addition of trastuzumab to paclitaxel after doxorubicin and cyclophosphamide in early-stage HER2-positive breast cancer results in a substantial and durable improvement in survival as a result of a sustained marked reduction in cancer recurrence.Copyright � 2014 by American Society of Clinical Oncology.

Powered by Koha