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The association between a medical history of depression and gestational diabetes in a large multi-ethnic cohort in the United States.

MedStar author(s):

0269-5022

Name of journal: Paediatric and perinatal epidemiologyAbstract: BACKGROUND: Both major depression and gestational diabetes mellitus (GDM) are prevalent among women of reproductive age. Our objective was to determine whether a medical history of depression is related to subsequent development of GDM.CONCLUSIONS: A history of depression was significantly associated with an increased GDM risk among a large multi-ethnic US cohort of women. If the association is confirmed, depression presents a potentially modifiable risk factor of GDM and provides additional clues to the underlying pathophysiology of GDM. Published 2013. This article is a U.S. Government work and is in the public domain in the USA.METHODS: The Consortium on Safe Labor was a US retrospective cohort study of 228,562 births between 2002 and 2008. Exclusion criteria for the present analysis included multiple gestation pregnancies (n=5059), pre-existing diabetes (n=12,771), deliveries <24 weeks (n=395), site GDM prevalence (<1%) (n=20,721) and missing data on pre-pregnancy body mass index (BMI) (n=61,321). Using generalised estimating equations, we estimated the association between a history of depression and a pregnancy complicated by GDM.RESULTS: The final analytic population included 121,260 women contributing 128295 pregnancies, of which 5606 were affected by GDM. A history of depression was significantly associated with an increased risk of developing GDM (multivariate odds ratio [aOR]=1.42 [95% confidence interval (CI) 1.26, 1.60]). Adjusting for pre-pregnancy BMI and weight gain during pregnancy attenuated the association, although it remained statistically significant (aOR=1.17 [95% CI 1.03, 1.33]).All authors: Bowers K, Brite J, Kiely M, Kim S, Laughon SK, Mumford SL, Zhang CDigital Object Identifier:

http://dx.doi.org/10.1111/ppe.12057

Date added to catalog: 2014-02-24

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Title notes ( 5 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article		Available		23772933

BACKGROUND: Both major depression and gestational diabetes mellitus (GDM) are prevalent among women of reproductive age. Our objective was to determine whether a medical history of depression is related to subsequent development of GDM.

CONCLUSIONS: A history of depression was significantly associated with an increased GDM risk among a large multi-ethnic US cohort of women. If the association is confirmed, depression presents a potentially modifiable risk factor of GDM and provides additional clues to the underlying pathophysiology of GDM. Published 2013. This article is a U.S. Government work and is in the public domain in the USA.

METHODS: The Consortium on Safe Labor was a US retrospective cohort study of 228,562 births between 2002 and 2008. Exclusion criteria for the present analysis included multiple gestation pregnancies (n=5059), pre-existing diabetes (n=12,771), deliveries <24 weeks (n=395), site GDM prevalence (<1%) (n=20,721) and missing data on pre-pregnancy body mass index (BMI) (n=61,321). Using generalised estimating equations, we estimated the association between a history of depression and a pregnancy complicated by GDM.

RESULTS: The final analytic population included 121,260 women contributing 128295 pregnancies, of which 5606 were affected by GDM. A history of depression was significantly associated with an increased risk of developing GDM (multivariate odds ratio [aOR]=1.42 [95% confidence interval (CI) 1.26, 1.60]). Adjusting for pre-pregnancy BMI and weight gain during pregnancy attenuated the association, although it remained statistically significant (aOR=1.17 [95% CI 1.03, 1.33]).

English