Longitudinal trajectories of arterial stiffness and the role of blood pressure: the Baltimore Longitudinal Study of Aging.

MedStar author(s):
Citation: Hypertension. 62(5):934-41, 2013 Nov.PMID: 24001897Institution: MedStar Heart & Vascular InstituteForm of publication: Journal ArticleMedline article type(s): Journal Article | Research Support, N.I.H., IntramuralSubject headings: *Aging/ph [Physiology] | *Blood Pressure/ph [Physiology] | *Carotid Arteries/ph [Physiology] | *Femoral Artery/ph [Physiology] | *Vascular Stiffness/ph [Physiology] | Adult | Aged | Aged, 80 and over | Baltimore | Blood Flow Velocity/ph [Physiology] | Blood Pressure Determination | Cardiovascular Diseases/pp [Physiopathology] | Female | Humans | Longitudinal Studies | Male | Middle Aged | Pulsatile Flow/ph [Physiology] | Pulse Wave Analysis | Risk FactorsLocal holdings: Available online from MWHC library: 1979 - presentISSN:
  • 0194-911X
Name of journal: HypertensionAbstract: Carotid-femoral pulse wave velocity (PWV), a marker of arterial stiffness, is an established independent cardiovascular risk factor. Little information is available on the pattern and determinants of the longitudinal 130224 in PWV with aging. Such information is crucial to elucidating mechanisms underlying arterial stiffness and the design of interventions to retard it. Between 1988 and 2013, we collected 2 to 9 serial measures of PWV in 354 men and 423 women of the Baltimore Longitudinal Study of Aging, who were 21 to 94 years of age and free of clinically significant cardiovascular disease. Rates of PWV increase accelerated with advancing age in men more than women, leading to sex differences in PWV after the age of 50 years. In both sexes, not only systolic blood pressure (SBP) >140 mmHg but also SBP of 120 to 139 mmHg was associated with steeper rates of PWV increase compared with SBP<120 mmHg. Furthermore, there was a dose-dependent effect of SBP in men with marked acceleration in PWV rate of increase with age at SBP >140 mmHg compared with SBP of 120 to 139 mmHg. Except for waist circumference in women, no other traditional cardiovascular risk factors predicted longitudinal PWV increase. In conclusion, the steeper longitudinal increase of PWV in men than women led to the sex difference that expanded with advancing age. Age and SBP are the main longitudinal determinants of PWV, and the effect of SBP on PWV trajectories exists even in the prehypertensive range.All authors: Alghatrif M, Canepa M, Elango P, Ferrucci L, Lakatta EG, Morrell CH, Najjar SS, Scuteri A, Strait JB, Wright JDigital Object Identifier: Date added to catalog: 2014-02-24
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Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article Available 24001897

Available online from MWHC library: 1979 - present

Carotid-femoral pulse wave velocity (PWV), a marker of arterial stiffness, is an established independent cardiovascular risk factor. Little information is available on the pattern and determinants of the longitudinal 130224 in PWV with aging. Such information is crucial to elucidating mechanisms underlying arterial stiffness and the design of interventions to retard it. Between 1988 and 2013, we collected 2 to 9 serial measures of PWV in 354 men and 423 women of the Baltimore Longitudinal Study of Aging, who were 21 to 94 years of age and free of clinically significant cardiovascular disease. Rates of PWV increase accelerated with advancing age in men more than women, leading to sex differences in PWV after the age of 50 years. In both sexes, not only systolic blood pressure (SBP) >140 mmHg but also SBP of 120 to 139 mmHg was associated with steeper rates of PWV increase compared with SBP<120 mmHg. Furthermore, there was a dose-dependent effect of SBP in men with marked acceleration in PWV rate of increase with age at SBP >140 mmHg compared with SBP of 120 to 139 mmHg. Except for waist circumference in women, no other traditional cardiovascular risk factors predicted longitudinal PWV increase. In conclusion, the steeper longitudinal increase of PWV in men than women led to the sex difference that expanded with advancing age. Age and SBP are the main longitudinal determinants of PWV, and the effect of SBP on PWV trajectories exists even in the prehypertensive range.

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