Epigenetics of progression of chronic kidney disease: fact or fantasy?.

MedStar author(s):
Citation: Seminars in Nephrology. 33(4):363-74, 2013 Jul.PMID: 24011578Institution: MedStar Health Research InstituteForm of publication: Journal ArticleMedline article type(s): Journal Article | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov'tSubject headings: *Epigenesis, Genetic | *Renal Insufficiency, Chronic/ge [Genetics] | Animals | Disease Progression | DNA Methylation | Epithelial-Mesenchymal Transition | Gene-Environment Interaction | Humans | Inflammation/ge [Genetics] | MicroRNAs/ph [Physiology] | Organ SpecificityLocal holdings: Available in print through MWHC library: 1999 - presentISSN:
  • 0270-9295
Name of journal: Seminars in nephrologyAbstract: Epigenetic modifications are important in the normal functioning of the cell, from regulating dynamic expression of essential genes and associated proteins to repressing those that are unneeded. Epigenetic changes are essential for development and functioning of the kidney, and aberrant methylation, histone modifications, and expression of microRNA could lead to chronic kidney disease (CKD). Here, epigenetic modifications modulate transforming growth factor beta signaling, inflammation, profibrotic genes, and the epithelial-to-mesenchymal transition, promoting renal fibrosis and progression of CKD. Identification of these epigenetic changes is important because they are potentially reversible and may serve as therapeutic targets in the future to prevent subsequent renal fibrosis and CKD. In this review we discuss the different types of epigenetic control, methods to study epigenetic modifications, and how epigenetics promotes progression of CKD. 2013 Elsevier Inc. All rights reserved.All authors: Devaney JM, Gill HS, Raj DS, Ramezani A, Wing MRDigital Object Identifier: Date added to catalog: 2014-04-04
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Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article Available 24011578

Available in print through MWHC library: 1999 - present

Epigenetic modifications are important in the normal functioning of the cell, from regulating dynamic expression of essential genes and associated proteins to repressing those that are unneeded. Epigenetic changes are essential for development and functioning of the kidney, and aberrant methylation, histone modifications, and expression of microRNA could lead to chronic kidney disease (CKD). Here, epigenetic modifications modulate transforming growth factor beta signaling, inflammation, profibrotic genes, and the epithelial-to-mesenchymal transition, promoting renal fibrosis and progression of CKD. Identification of these epigenetic changes is important because they are potentially reversible and may serve as therapeutic targets in the future to prevent subsequent renal fibrosis and CKD. In this review we discuss the different types of epigenetic control, methods to study epigenetic modifications, and how epigenetics promotes progression of CKD. 2013 Elsevier Inc. All rights reserved.

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