Ovarian reserve and subsequent assisted reproduction outcomes after methotrexate therapy for ectopic pregnancy or pregnancy of unknown location.

MedStar author(s):
Citation: Fertility & Sterility. 101(2):413-9, 2014 Feb.PMID: 24269042Institution: MedStar Washington Hospital CenterDepartment: Obstetrics and GynecologyForm of publication: Journal ArticleMedline article type(s): Journal Article | Research Support, N.I.H., ExtramuralSubject headings: *Methotrexate/tu [Therapeutic Use] | *Oocyte Retrieval/td [Trends] | *Pregnancy, Ectopic/dt [Drug Therapy] | *Pregnancy, Ectopic/su [Surgery] | *Reproductive Techniques, Assisted/td [Trends] | Adult | Cohort Studies | Female | Humans | Pregnancy | Pregnancy, Ectopic/di [Diagnosis] | Retrospective Studies | Treatment OutcomeLocal holdings: Available online from MWHC library: 1997 - present, Available in print through MWHC library:1999-2007ISSN:
  • 0015-0282
Name of journal: Fertility and sterilityAbstract: CONCLUSION(S): Ovarian reserve and subsequent ART cycle outcomes were reassuring after methotrexate or surgical management of ectopic pregnancy. No adverse impact of methotrexate was detected in this large fertility cohort as has been previously described elsewhere. Published by Elsevier Inc.DESIGN: Retrospective cohort study.INTERVENTION(S): None.MAIN OUTCOME MEASURE(S): Follicle-stimulating hormone (FSH), antral follicle count (AFC), and oocyte yield compared between women treated with methotrexate or surgery, with secondary outcomes of clinical pregnancy and live birth.OBJECTIVE: To assess ovarian reserve after methotrexate treatment for ectopic pregnancy or pregnancy of unknown location after assisted reproductive technology (ART).PATIENT(S): Women receiving methotrexate or surgery after ART.RESULT(S): There were 153 patients in the methotrexate group and 36 patients in the surgery group. Neither group demonstrated differences in ovarian reserve or oocyte yield in a comparison of the before and after treatment values. The 20140821 in ovarian reserve and oocyte yield after treatment were similar between the two groups. The number of doses of methotrexate was not correlated with 140821s in ovarian reserve, indicating no dose-dependent effect. Time between treatment and repeat ART was not correlated with outcomes. Live birth in subsequent cycles was similar in the two groups.SETTING: Large ART practice.All authors: Alford C, Cooper JC, DeCherney AH, Hill MJ, Katz CL, Levens ED, Levy G, Richter KS, Wolff EFDigital Object Identifier: Date added to catalog: 2014-08-21
Holdings
Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article Available 24269042

Available online from MWHC library: 1997 - present, Available in print through MWHC library:1999-2007

CONCLUSION(S): Ovarian reserve and subsequent ART cycle outcomes were reassuring after methotrexate or surgical management of ectopic pregnancy. No adverse impact of methotrexate was detected in this large fertility cohort as has been previously described elsewhere. Published by Elsevier Inc.

DESIGN: Retrospective cohort study.

INTERVENTION(S): None.

MAIN OUTCOME MEASURE(S): Follicle-stimulating hormone (FSH), antral follicle count (AFC), and oocyte yield compared between women treated with methotrexate or surgery, with secondary outcomes of clinical pregnancy and live birth.

OBJECTIVE: To assess ovarian reserve after methotrexate treatment for ectopic pregnancy or pregnancy of unknown location after assisted reproductive technology (ART).

PATIENT(S): Women receiving methotrexate or surgery after ART.

RESULT(S): There were 153 patients in the methotrexate group and 36 patients in the surgery group. Neither group demonstrated differences in ovarian reserve or oocyte yield in a comparison of the before and after treatment values. The 20140821 in ovarian reserve and oocyte yield after treatment were similar between the two groups. The number of doses of methotrexate was not correlated with 140821s in ovarian reserve, indicating no dose-dependent effect. Time between treatment and repeat ART was not correlated with outcomes. Live birth in subsequent cycles was similar in the two groups.

SETTING: Large ART practice.

English

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