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Differences in risk factors for incident and recurrent small-for-gestational-age birthweight: a hospital-based cohort study.

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Citation: BJOG: An International Journal of Obstetrics & Gynaecology. 121(9):1080-8; discussion 1089, 2014 Aug.PMID: 24702952Institution: MedStar Washington Hospital CenterDepartment: Obstetrics and Gynecology, Maternal-Fetal MedicineForm of publication: Journal ArticleMedline article type(s): Journal Article | Research Support, N.I.H., IntramuralSubject headings: *Infant, Small for Gestational Age | Adolescent | Adult | Female | Humans | Incidence | Infant, Newborn | Middle Aged | Pregnancy | Recurrence | Retrospective Studies | Risk Factors | Utah/ep [Epidemiology] | Young AdultLocal holdings: Available online from MWHC library: 1997 - presentISSN:

1470-0328

Name of journal: BJOG : an international journal of obstetrics and gynaecologyAbstract: CONCLUSION: There was considerable overlap in the risk factors for SGA recurrence and incidence. Recurrence and incidence risk factors included smoking, short stature, underweight, and inadequate weight gain. Maternal age and hypertensive diseases increased the risk for incidence only. Regardless of the SGA definition, some potentially modifiable risk factors for recurrence were identified. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.DESIGN: Hospital-based cohort study.MAIN OUTCOME MEASURES: Second pregnancy incident (n = 1067) and recurrent SGA (n = 484) determined using a population-based reference.METHODS: Estimated adjusted relative risks (RR) and 95% confidence intervals (95% CI) for the association between second pregnancy characteristics and SGA risk. Tested for risk factor differences between recurrence and incidence (Pdifference).OBJECTIVE: Examine whether small-for-gestational-age (SGA) risk factors differed by prior SGA birth.POPULATION: Electronic medical record data from 25,241 women who were nulliparous at study entry with >2 subsequent consecutive singleton deliveries (2002-2010).RESULTS: SGA complicated 20.3 and 4.5% of deliveries to women with and without a prior SGA birth, respectively. Young maternal age (Pdifference = 0.01) and pregnancy hypertensive diseases (Pdifference = 0.03) were associated with incident but not recurrent SGA. Significant risk factors for incidence and recurrence were smoking (incident RR = 1.64 [95% CI 1.22-2.19]; recurrent RR = 1.59 [95% CI 1.17-2.17]), short stature (incident RR = 1.34 [95% CI 1.16-1.54]; recurrent RR = 1.54 [95% CI 1.31-1.82]), prepregnancy underweight (incident RR = 1.32 [95% CI 1.07-1.64]; recurrent RR = 1.30 [95% CI 1.03-1.64]), and inadequate weight gain (incident RR = 1.41 [95% CI 1.22-1.64]; recurrent RR = 1.33 [95% CI 1.10-1.60]). Race-ethnicity, marital or insurance status, alcohol, diabetes, asthma, thyroid disease, depression, or interpregnancy interval were not associated with incidence or recurrence.SETTING: Utah, USA.All authors: Albert PS, Boghossian NS, Hinkle SN, Laughon SK, Mendola P, Sjaarda LA, Yeung EDigital Object Identifier:

http://dx.doi.org/10.1111/1471-0528.12628

Date added to catalog: 2014-09-23

Holdings ( 1 )
Title notes ( 10 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article		Available		24702952

Available online from MWHC library: 1997 - present

CONCLUSION: There was considerable overlap in the risk factors for SGA recurrence and incidence. Recurrence and incidence risk factors included smoking, short stature, underweight, and inadequate weight gain. Maternal age and hypertensive diseases increased the risk for incidence only. Regardless of the SGA definition, some potentially modifiable risk factors for recurrence were identified. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.

DESIGN: Hospital-based cohort study.

MAIN OUTCOME MEASURES: Second pregnancy incident (n = 1067) and recurrent SGA (n = 484) determined using a population-based reference.

METHODS: Estimated adjusted relative risks (RR) and 95% confidence intervals (95% CI) for the association between second pregnancy characteristics and SGA risk. Tested for risk factor differences between recurrence and incidence (Pdifference).

OBJECTIVE: Examine whether small-for-gestational-age (SGA) risk factors differed by prior SGA birth.

POPULATION: Electronic medical record data from 25,241 women who were nulliparous at study entry with >2 subsequent consecutive singleton deliveries (2002-2010).

RESULTS: SGA complicated 20.3 and 4.5% of deliveries to women with and without a prior SGA birth, respectively. Young maternal age (Pdifference = 0.01) and pregnancy hypertensive diseases (Pdifference = 0.03) were associated with incident but not recurrent SGA. Significant risk factors for incidence and recurrence were smoking (incident RR = 1.64 [95% CI 1.22-2.19]; recurrent RR = 1.59 [95% CI 1.17-2.17]), short stature (incident RR = 1.34 [95% CI 1.16-1.54]; recurrent RR = 1.54 [95% CI 1.31-1.82]), prepregnancy underweight (incident RR = 1.32 [95% CI 1.07-1.64]; recurrent RR = 1.30 [95% CI 1.03-1.64]), and inadequate weight gain (incident RR = 1.41 [95% CI 1.22-1.64]; recurrent RR = 1.33 [95% CI 1.10-1.60]). Race-ethnicity, marital or insurance status, alcohol, diabetes, asthma, thyroid disease, depression, or interpregnancy interval were not associated with incidence or recurrence.

SETTING: Utah, USA.

English