Lung function and heart disease in American Indian adults with high frequency of metabolic abnormalities (from the Strong Heart Study).

MedStar author(s):
Citation: American Journal of Cardiology. 114(2):312-9, 2014 Jul 15.PMID: 24878118Form of publication: Journal ArticleMedline article type(s): Journal Article | Multicenter Study | Research Support, N.I.H., ExtramuralSubject headings: *Heart Diseases/eh [Ethnology] | *Indians, North American | *Lung/pp [Physiopathology] | *Metabolic Syndrome X/eh [Ethnology] | *Population Surveillance/mt [Methods] | Aged | Female | Follow-Up Studies | Heart Diseases/co [Complications] | Heart Diseases/pp [Physiopathology] | Humans | Incidence | Male | Metabolic Syndrome X/co [Complications] | Metabolic Syndrome X/pp [Physiopathology] | Middle Aged | Predictive Value of Tests | Prevalence | Prognosis | Prospective Studies | Risk Factors | Spirometry | United States/ep [Epidemiology] | Vital CapacityLocal holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006ISSN:
  • 0002-9149
Name of journal: The American journal of cardiologyAbstract: The associations of pulmonary function with cardiovascular disease (CVD) independent of diabetes mellitus (DM) and metabolic syndrome have not been examined in a population-based setting. We examined prevalence and incidence CVD in relation to lower pulmonary function in the Strong Heart Study second examination (1993 to 1995) in 352 CVD and 2,873 non-CVD adults free of overt lung disease (mean age 60 years). Lung function was assessed by standard spirometry. Participants with metabolic syndrome or DM with or without CVD had lower pulmonary function than participants without these conditions after adjustment for hypertension, age, gender, abdominal obesity, smoking, physical activity index, and study field center. CVD participants with DM had significantly lower forced vital capacity than participants with CVD alone. Significant associations were observed between reduced pulmonary function, preclinical CVD, and prevalent CVD after adjustment for multiple CVD risk factors. During follow-up (median 13.3 years), pulmonary function did not predict CVD incidence, it predicted CVD mortality. Among 3,225 participants, 412 (298 without baseline CVD) died from CVD by the end of 2008. In models adjusted for multiple CVD risk factors, DM, metabolic syndrome, and baseline CVD, compared with highest quartile of lung function, lower lung function predicted CVD mortality (relative risk up to 1.5, 95% confidence interval 1.1 to 2.0, p<0.05). In conclusion, a population with a high prevalence of DM and metabolic syndrome and lower lung function was independently associated with prevalent clinical and preclinical CVD, and its impairment predicted CVD mortality. Additional research is needed to identify mechanisms linking metabolic abnormalities, low lung function, and CVD. Copyright 2014 Elsevier Inc. All rights reserved.All authors: Ali T, Best LG, Devereux RB, Dixon AE, Howard BV, Lee ET, Marion SM, Rhoades ER, Yeh F, Yeh JDigital Object Identifier: Date added to catalog: 2014-09-12
Holdings
Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article Available 24878118

Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006

The associations of pulmonary function with cardiovascular disease (CVD) independent of diabetes mellitus (DM) and metabolic syndrome have not been examined in a population-based setting. We examined prevalence and incidence CVD in relation to lower pulmonary function in the Strong Heart Study second examination (1993 to 1995) in 352 CVD and 2,873 non-CVD adults free of overt lung disease (mean age 60 years). Lung function was assessed by standard spirometry. Participants with metabolic syndrome or DM with or without CVD had lower pulmonary function than participants without these conditions after adjustment for hypertension, age, gender, abdominal obesity, smoking, physical activity index, and study field center. CVD participants with DM had significantly lower forced vital capacity than participants with CVD alone. Significant associations were observed between reduced pulmonary function, preclinical CVD, and prevalent CVD after adjustment for multiple CVD risk factors. During follow-up (median 13.3 years), pulmonary function did not predict CVD incidence, it predicted CVD mortality. Among 3,225 participants, 412 (298 without baseline CVD) died from CVD by the end of 2008. In models adjusted for multiple CVD risk factors, DM, metabolic syndrome, and baseline CVD, compared with highest quartile of lung function, lower lung function predicted CVD mortality (relative risk up to 1.5, 95% confidence interval 1.1 to 2.0, p<0.05). In conclusion, a population with a high prevalence of DM and metabolic syndrome and lower lung function was independently associated with prevalent clinical and preclinical CVD, and its impairment predicted CVD mortality. Additional research is needed to identify mechanisms linking metabolic abnormalities, low lung function, and CVD. Copyright 2014 Elsevier Inc. All rights reserved.

English

Powered by Koha