Developing trends in the intestinal transplant waitlist.

MedStar author(s):
Citation: American Journal of Transplantation. 14(12):2830-7, 2014 Dec.PMID: 25395218Institution: MedStar Health Research Institute | MedStar Washington Hospital CenterDepartment: Surgery/TransplantationForm of publication: Journal ArticleMedline article type(s): Journal Article | Research Support, U.S. Gov't, P.H.S.Subject headings: *Intestines/tr [Transplantation] | *Mortality/td [Trends] | *Organ Transplantation/mo [Mortality] | *Organ Transplantation/sn [Statistics & Numerical Data] | *Tissue and Organ Procurement/sn [Statistics & Numerical Data] | *Waiting Lists/mo [Mortality] | Adolescent | Adult | Age Factors | Child | Child, Preschool | Female | Follow-Up Studies | Humans | Infant | Infant, Newborn | Male | Prognosis | Survival Rate | Young AdultLocal holdings: Available online from MWHC library: May 2001 - presentISSN:
  • 1600-6135
Name of journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsAbstract: The United Network for Organ Sharing database was examined for trends in the intestinal transplant (ITx) waitlist from 1993 to 2012, dividing into listings for isolated ITx versus liver-intestine transplant (L-ITx). Registrants added to the waitlist increased from 59/year in 1993 to 317/year in 2006, then declined to 124/year in 2012; Spline modeling showed a significant change in the trend in 2006, p<0.001. The largest group of registrants, <1year of age, determined the trend for the entire population; other pediatric age groups remained stable, adult registrants increased until 2012. The largest proportion of new registrants were for L-ITx, compared to isolated ITx; the change in the trend in 2006 for L-ITx was highly significant, p<0.001, but not isolated ITx, p=0.270. New registrants for L-ITx, <1year of age, had the greatest increase and decrease. New registrants for isolated ITx remained constant in all pediatric age groups. Waitlist mortality increased to a peak around 2002, highest for L-ITx, in patients <1year of age and adults. Deaths among all pediatric age groups awaiting L-ITx have decreased; adult L-ITx deaths have dropped less dramatically. Improved care of infants with intestinal failure has led to reduced referrals for L-ITx. � Copyright 2014 The American Society of Transplantation and the American Society of Transplant Surgeons.All authors: Desai CS, Desale S, Fishbein T, Girlanda R, Hawksworth J, Kaufman S, Khan KM, Matsumoto C, Mete MDigital Object Identifier: Date added to catalog: 2016-01-13
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Journal Article MedStar Authors Catalog Article Available 25395218

Available online from MWHC library: May 2001 - present

The United Network for Organ Sharing database was examined for trends in the intestinal transplant (ITx) waitlist from 1993 to 2012, dividing into listings for isolated ITx versus liver-intestine transplant (L-ITx). Registrants added to the waitlist increased from 59/year in 1993 to 317/year in 2006, then declined to 124/year in 2012; Spline modeling showed a significant change in the trend in 2006, p<0.001. The largest group of registrants, <1year of age, determined the trend for the entire population; other pediatric age groups remained stable, adult registrants increased until 2012. The largest proportion of new registrants were for L-ITx, compared to isolated ITx; the change in the trend in 2006 for L-ITx was highly significant, p<0.001, but not isolated ITx, p=0.270. New registrants for L-ITx, <1year of age, had the greatest increase and decrease. New registrants for isolated ITx remained constant in all pediatric age groups. Waitlist mortality increased to a peak around 2002, highest for L-ITx, in patients <1year of age and adults. Deaths among all pediatric age groups awaiting L-ITx have decreased; adult L-ITx deaths have dropped less dramatically. Improved care of infants with intestinal failure has led to reduced referrals for L-ITx. � Copyright 2014 The American Society of Transplantation and the American Society of Transplant Surgeons.

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