Opioid treatment of experimental pain activates nuclear factor-kappaB.
Citation: Journal of Opioid Management. 11(2):115-25, 2015 Mar-Apr.PMID: 25901477Institution: MedStar Health Research InstituteForm of publication: Journal ArticleMedline article type(s): Journal Article | Observational Study | Randomized Controlled Trial | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov'tSubject headings: *Analgesics, Opioid/tu [Therapeutic Use] | *Fentanyl/tu [Therapeutic Use] | *NF-kappa B/bl [Blood] | *Pain/dt [Drug Therapy] | Adult | Female | Follow-Up Studies | Healthy Volunteers | Humans | Injections, Intravenous | Male | Monocytes/de [Drug Effects] | Pain/bl [Blood] | Signal Transduction/de [Drug Effects]Year: 2015ISSN:- 1551-7489
Item type | Current library | Collection | Call number | Status | Date due | Barcode |
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Journal Article | MedStar Authors Catalog | Article | 25901477 | Available | 25901477 |
CONCLUSIONS: The combination of acute pain with opioids, as occurs in clinical situations, activates a key transcription factor involved in proinflammatory responses.
DESIGN: NF-kappaB activation was compared within-subjects following four randomly ordered experimental sessions of opioid-only (intravenous fentanyl 1 mug/kg), painonly (cold-pressor), opioid + pain, and a resting condition.
INTERVENTIONS: Following exposure to treatment (fentanyl administration and/or cold-pressor pain), blood samples for NF-kappaB analysis were obtained.
MAIN OUTCOME MEASURES: Intracellular levels of activated NF-kappaB, in unstimulated and stimulated peripheral blood mononuclear cells at 15 and 30 minutes.
OBJECTIVE: To determine the independent and combined effects of pain and opioids on the activation of an early marker of inflammation, nuclear factor-kappaB (NF-kappaB).
PARTICIPANTS: Twenty-one (11 female) healthy controls.
RESULTS: Neither pain nor opioid administration alone effected NF-kappaB levels in cell populations; however, the combination of treatments induced significant increases of NF-kappaB in stimulated peripheral blood mononuclear cell, lymphocytes, and monocytes.
SETTING: University General Clinical Research Center.
English