Intravascular ultrasound analysis to determine the relationship between high-density lipoprotein cholesterol and lesion characteristics in patients with coronary artery disease.

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Citation: Journal of Interventional Cardiology. 27(3):325-33, 2014 Jun.PMID: 24517632Institution: MedStar Health Research Institute | MedStar Heart & Vascular InstituteForm of publication: Journal ArticleMedline article type(s): Journal Article | Randomized Controlled TrialSubject headings: *Cholesterol, HDL/me [Metabolism] | *Coronary Artery Disease | *Percutaneous Coronary Intervention/mt [Methods] | *Plaque, Atherosclerotic | Aged | Coronary Angiography/mt [Methods] | Coronary Artery Disease/di [Diagnosis] | Coronary Artery Disease/me [Metabolism] | Coronary Artery Disease/th [Therapy] | Female | Humans | Male | Middle Aged | Plaque, Atherosclerotic/pa [Pathology] | Plaque, Atherosclerotic/us [Ultrasonography] | Predictive Value of Tests | Preoperative Care/mt [Methods] | Risk Assessment | Statistics as Topic | Ultrasonography, Interventional/mt [Methods]Year: 2014ISSN:
  • 0896-4327
Name of journal: Journal of interventional cardiologyAbstract: BACKGROUND: Low HDL-C is associated with an increased risk of cardiovascular events. Previous IVUS studies have suggested a significant association between lesion characteristics and cardiovascular events.CONCLUSIONS: Patients with low levels of HDL-C may be at increased risk of having a higher incidence of attenuated plaques.Copyright © 2014, Wiley Periodicals, Inc.METHODS: According to HDL-C levels, 120 patients who underwent IVUS for native, de novo coronary lesions before any intervention were divided into a low HDL-C group (<40mg/dL, n=60) and a high HDL-C group (>40mg/dL, n=60). Quantitative and qualitative IVUS analyses were performed to compare lesion characteristics.OBJECTIVES: This study utilized grayscale intravascular ultrasound (IVUS) to explore the relationship between high-density lipoprotein cholesterol (HDL-C) levels and culprit lesion characteristics in patients with coronary artery disease.RESULTS: Quantitative IVUS measurements showed no significant differences between the 2 groups. HDL-C level was not significantly correlated with remodeling index (r=0.03, P=0.78). However, attenuated plaque was more frequent in the low HDL-C group (48.3% vs. 28.3%, P=0.02) and a greater percentage of attenuated plaque was found in this group (32.5+/-21.3% vs. 21.0+/-11.0%, P=0.02). Moreover, when categorized into 4 groups according to HDL-C levels, the proportion of attenuated plaque (64.7% in group with <30mg/dL, 41.9% in group with 30-39mg/dL, 36.4% in group with 40-59mg/dL, and 6.3% in group with >60mg/dL; P=0.001 for trend) was significantly different among groups. On multivariate analysis, only HDL-C and male gender were independently associated with the presence of attenuated plaque at the culprit lesions.All authors: Brewer HB Jr, Chen F, Kitabata H, Loh JP, Magalhaes MA, Omar A, Pendyala LK, Pichard AD, Torguson R, Waksman RFiscal year: FY2014Date added to catalog: 2016-05-24
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Journal Article MedStar Authors Catalog 24517632 Available 24517632

BACKGROUND: Low HDL-C is associated with an increased risk of cardiovascular events. Previous IVUS studies have suggested a significant association between lesion characteristics and cardiovascular events.

CONCLUSIONS: Patients with low levels of HDL-C may be at increased risk of having a higher incidence of attenuated plaques.Copyright © 2014, Wiley Periodicals, Inc.

METHODS: According to HDL-C levels, 120 patients who underwent IVUS for native, de novo coronary lesions before any intervention were divided into a low HDL-C group (<40mg/dL, n=60) and a high HDL-C group (>40mg/dL, n=60). Quantitative and qualitative IVUS analyses were performed to compare lesion characteristics.

OBJECTIVES: This study utilized grayscale intravascular ultrasound (IVUS) to explore the relationship between high-density lipoprotein cholesterol (HDL-C) levels and culprit lesion characteristics in patients with coronary artery disease.

RESULTS: Quantitative IVUS measurements showed no significant differences between the 2 groups. HDL-C level was not significantly correlated with remodeling index (r=0.03, P=0.78). However, attenuated plaque was more frequent in the low HDL-C group (48.3% vs. 28.3%, P=0.02) and a greater percentage of attenuated plaque was found in this group (32.5+/-21.3% vs. 21.0+/-11.0%, P=0.02). Moreover, when categorized into 4 groups according to HDL-C levels, the proportion of attenuated plaque (64.7% in group with <30mg/dL, 41.9% in group with 30-39mg/dL, 36.4% in group with 40-59mg/dL, and 6.3% in group with >60mg/dL; P=0.001 for trend) was significantly different among groups. On multivariate analysis, only HDL-C and male gender were independently associated with the presence of attenuated plaque at the culprit lesions.

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