Evaluating the potential benefits of metformin in patients with cardiovascular disease and heart failure.

MedStar author(s):
Citation: Consultant Pharmacist. 28(9):579-83, 2013 Sep.PMID: 24007890Institution: MedStar Union Memorial HospitalDepartment: PharmacyForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Cardiovascular Diseases/dt [Drug Therapy] | *Diabetes Mellitus, Type 2/dt [Drug Therapy] | *Heart Failure/dt [Drug Therapy] | *Metformin/tu [Therapeutic Use] | Humans | Hypoglycemic Agents/tu [Therapeutic Use] | Randomized Controlled Trials as TopicYear: 2013ISSN:
  • 0888-5109
Name of journal: The Consultant pharmacist : the journal of the American Society of Consultant PharmacistsAbstract: CONCLUSIONS: Results from recent trials have evaluated the potential clinical advantages of metformin in patients with cardiac disease and HF. These studies have illustrated a favorable morbidity and mortality profile for the use of metformin in these patient populations. While large prospective trials are still needed to display conclusive evidence, the recent clinical trials suggest a benefit in areas where metformin use has previously been discouraged.DATA SOURCES: Searches of MEDLINE and International Pharmaceutical Abstracts (1966-August 2012). Search terms included metformin, lactic acidosis, cardiovascular disease, diabetes, heart failure, and clinical trials.DATA SYNTHESIS: Case reports and retrospective trials have failed to illustrate an association with metformin use and lactic acidosis in patients with HF or cardiac disease. In fact, the evidence has suggested that these patients may actually benefit from the use of metformin.OBJECTIVE: To examine the safety and potential benefits of metformin in diabetic patients with cardiovascular (CV) disease and heart failure (HF).STUDY SELECTION AND DATA EXTRACTION: Published studies and case reports that were chosen for inclusion evaluated the benefit and safety of metformin in patients with diabetes with CV disease and HF.All authors: Amin SM, Chilipko AA, Macharia D, Norwood DK, Still KLFiscal year: FY2014Digital Object Identifier: Date added to catalog: 2016-07-15
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Journal Article MedStar Authors Catalog Article 24007890 Available 24007890

CONCLUSIONS: Results from recent trials have evaluated the potential clinical advantages of metformin in patients with cardiac disease and HF. These studies have illustrated a favorable morbidity and mortality profile for the use of metformin in these patient populations. While large prospective trials are still needed to display conclusive evidence, the recent clinical trials suggest a benefit in areas where metformin use has previously been discouraged.

DATA SOURCES: Searches of MEDLINE and International Pharmaceutical Abstracts (1966-August 2012). Search terms included metformin, lactic acidosis, cardiovascular disease, diabetes, heart failure, and clinical trials.

DATA SYNTHESIS: Case reports and retrospective trials have failed to illustrate an association with metformin use and lactic acidosis in patients with HF or cardiac disease. In fact, the evidence has suggested that these patients may actually benefit from the use of metformin.

OBJECTIVE: To examine the safety and potential benefits of metformin in diabetic patients with cardiovascular (CV) disease and heart failure (HF).

STUDY SELECTION AND DATA EXTRACTION: Published studies and case reports that were chosen for inclusion evaluated the benefit and safety of metformin in patients with diabetes with CV disease and HF.

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