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Granular cell differentiation: A review of the published work. [Review]

MedStar author(s):

Citation: Journal of Dermatology. 44(3):251-258, 2017 MarPMID: 28256763Institution: MedStar Washington Hospital CenterDepartment: DermatologyForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: *Cell Differentiation | *Granular Cell Tumor/pa [Pathology] | Humans | Neoplasms/pa [Pathology] | Neoplasms/pp [Physiopathology] | Skin Neoplasms/pa [Pathology]Year: 2017 ISSN:

0385-2407

Name of journal: The Journal of dermatologyAbstract: Copyright © 2017 Japanese Dermatological Association.Since the initial description of the granular cell tumor in 1926, numerous other neoplasms, both benign and malignant, have been described to exhibit granular cell change. In most cases, diagnosis remains straightforward via recognition of retained histopathological morphology of the archetypal tumor, despite the presence of focal granular appearance. However, tumors with granular cell differentiation can present a diagnostic challenge either by mimicking alternative diagnoses, or by failing to exhibit architectural clues of the primary entity, thus requiring an immunohistochemical work-up. In light of this, it is important to be aware of the various entities that have been reported to exhibit granular cell morphology. In this review such tumors are discussed along with pertinent clinical and histopathological features.All authors: Bhawan J, Cardis MA, Ni JFiscal year: FY2017Digital Object Identifier:

https://dx.doi.org/10.1111/1346-8138.13758

Date added to catalog: 2017-04-10

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Title notes ( 3 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	28256763	Available		28256763

Since the initial description of the granular cell tumor in 1926, numerous other neoplasms, both benign and malignant, have been described to exhibit granular cell change. In most cases, diagnosis remains straightforward via recognition of retained histopathological morphology of the archetypal tumor, despite the presence of focal granular appearance. However, tumors with granular cell differentiation can present a diagnostic challenge either by mimicking alternative diagnoses, or by failing to exhibit architectural clues of the primary entity, thus requiring an immunohistochemical work-up. In light of this, it is important to be aware of the various entities that have been reported to exhibit granular cell morphology. In this review such tumors are discussed along with pertinent clinical and histopathological features.

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