Do 25-Hydroxyvitamin D Levels Correlate With Fracture Complications?.
Citation: Journal of Orthopaedic Trauma. 30(9):e312-7, 2016 SepPMID: 27253482Institution: MedStar Washington Hospital CenterDepartment: Surgery/Orthopaedic SurgeryForm of publication: Journal ArticleMedline article type(s): Controlled Clinical Trial | Journal ArticleSubject headings: *Fractures, Bone/bl [Blood] | *Fractures, Bone/ep [Epidemiology] | *Postoperative Complications/bl [Blood] | *Postoperative Complications/ep [Epidemiology] | *Reoperation/ut [Utilization] | *Vitamin D/aa [Analogs & Derivatives] | Adolescent | Adult | Aged | Aged, 80 and over | Biomarkers/bl [Blood] | Bone Density Conservation Agents/tu [Therapeutic Use] | Calcium/tu [Therapeutic Use] | Female | Fractures, Bone/dt [Drug Therapy] | Humans | Male | Middle Aged | Missouri/ep [Epidemiology] | Postoperative Complications/pc [Prevention & Control] | Prevalence | Prognosis | Prospective Studies | Reproducibility of Results | Risk Assessment/mt [Methods] | Sensitivity and Specificity | Statistics as Topic | Treatment Outcome | Vitamin D/bl [Blood] | Vitamin D/tu [Therapeutic Use] | Young AdultYear: 2016Local holdings: Available online from MWHC library: 1996 - presentISSN:- 0890-5339
Item type | Current library | Collection | Call number | Status | Date due | Barcode |
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Journal Article | MedStar Authors Catalog | Article | 27253482 | Available | 27253482 |
Available online from MWHC library: 1996 - present
CONCLUSIONS: Serum 25(OH)D levels did not significantly affect the likelihood of fracture healing complications requiring surgery or any nonorthopaedic injury-related surgery.
DESIGN: Retrospective case series.
INTERVENTION: All patients received 1000 IU of vitamin D3 and 1500 mg of calcium daily. Vitamin D deficient and insufficient patients also received 50,000 IU of ergocalciferol (vitamin D2) weekly until 25(OH)D levels normalized or fractures healed.
LEVEL OF EVIDENCE: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
MAIN OUTCOME MEASUREMENTS: fracture complications and 25(OH)D levels.
OBJECTIVES: To determine the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and the likelihood of postoperative complications and fracture reoperation rate in orthopaedic trauma patients receiving vitamin D and calcium supplementation.
PATIENTS: All orthopaedic trauma patients-18 years or older-over a 20-month period were included with available initial and repeat 25(OH)D serum levels. In total, 201 patients met inclusion criteria.
RESULTS: Fifteen patients experienced postoperative healing complications. There was no significant difference between initial (P = 0.92) or repeat (P = 0.91) 25(OH)D levels between patients with and without fracture healing complications. Twenty-eight patients required repeat orthopaedic surgery. There was no significant difference between initial (P = 0.62) or repeat (P = 0.18) 25(OH)D levels between patients who did or did not require repeat orthopaedic surgery. There was no significant difference between initial (P = 0.66) or repeat (P = 0.89) 25(OH)D levels between patients who did or did not require nonorthopaedic surgery.
SETTING: Level I trauma center, Midwestern United States.
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