The association between hemoglobin concentration and neurologic outcome after cardiac arrest.

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Citation: Journal of Critical Care. 36:218-222, 2016 DecPMID: 27546775Institution: MedStar Washington Hospital CenterDepartment: Emergency MedicineForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Anemia/ep [Epidemiology] | *Cardiopulmonary Resuscitation/mt [Methods] | *Heart Arrest/th [Therapy] | *Hemoglobins/me [Metabolism] | *Hypothermia, Induced/mt [Methods] | *Hypoxia, Brain/pp [Physiopathology] | *Registries | Adult | Aged | Aged, 80 and over | Anemia/me [Metabolism] | Cohort Studies | Comorbidity | Female | Heart Arrest/co [Complications] | Heart Arrest/ep [Epidemiology] | Heart Arrest/me [Metabolism] | Humans | Hypoxia, Brain/et [Etiology] | Male | Middle Aged | Neoplasms/ep [Epidemiology] | Odds Ratio | Renal Insufficiency/ep [Epidemiology] | Retrospective Studies | Survival Rate | Treatment OutcomeYear: 2016Local holdings: Available online through MWHC library: 2012 - presentISSN:
  • 0883-9441
Name of journal: Journal of critical careAbstract: CONCLUSION: Higher Hgb after cardiac arrest is associated with favorable neurologic outcome, particularly within the first 6 hours. It is unclear if this effect is due to impaired oxygen delivery or if Hgb is a marker for more severe illness.Copyright (c) 2016 Elsevier Inc. All rights reserved.METHODS: We conducted a retrospective cohort study using the Penn Alliance for Therapeutic Hypothermia (PATH) cardiac arrest registry. Inclusion criteria were resuscitated cardiac arrest (inhospital or out of hospital) and an Hgb value recorded within 24 hours of return of spontaneous circulation. The primary outcome was favorable neurologic status at hospital discharge. Survival to hospital discharge was a secondary outcome.PURPOSE: The purpose of the study is to determine the association between hemoglobin concentration (Hgb) and neurologic outcome in postarrest patients.RESULTS: There were 598 eligible patients from 21 hospitals. Patients with favorable neurologic outcome had significantly higher median Hgb in the first 2 hours (12.7 vs 10.5 g/dL; P<.001) and 6 hours (12.6 vs 10.6 g/dL; P<.001) postarrest. Controlling for age, pulseless rhythm, etiology, location of arrest, receipt of targeted temperature management, hematologic or metastatic malignancy, or preexisting renal insufficiency, there was a significant relationship between Hgb and neurologic outcome within the first 6 hours after arrest (odds ratio, 1.23; 95% confidence interval, 1.09-1.38) and survival to hospital discharge (odds ratio, 1.20; 95% confidence interval, 1.08-1.34).All authors: Dodampahala K, Gaieski DF, Goyal M, Grossestreuer AV, Johnson NJ, Perman SM, Rosselot BFiscal year: FY2016Digital Object Identifier: Date added to catalog: 2017-05-24
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Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 27546775 Available 27546775

Available online through MWHC library: 2012 - present

CONCLUSION: Higher Hgb after cardiac arrest is associated with favorable neurologic outcome, particularly within the first 6 hours. It is unclear if this effect is due to impaired oxygen delivery or if Hgb is a marker for more severe illness.

Copyright (c) 2016 Elsevier Inc. All rights reserved.

METHODS: We conducted a retrospective cohort study using the Penn Alliance for Therapeutic Hypothermia (PATH) cardiac arrest registry. Inclusion criteria were resuscitated cardiac arrest (inhospital or out of hospital) and an Hgb value recorded within 24 hours of return of spontaneous circulation. The primary outcome was favorable neurologic status at hospital discharge. Survival to hospital discharge was a secondary outcome.

PURPOSE: The purpose of the study is to determine the association between hemoglobin concentration (Hgb) and neurologic outcome in postarrest patients.

RESULTS: There were 598 eligible patients from 21 hospitals. Patients with favorable neurologic outcome had significantly higher median Hgb in the first 2 hours (12.7 vs 10.5 g/dL; P<.001) and 6 hours (12.6 vs 10.6 g/dL; P<.001) postarrest. Controlling for age, pulseless rhythm, etiology, location of arrest, receipt of targeted temperature management, hematologic or metastatic malignancy, or preexisting renal insufficiency, there was a significant relationship between Hgb and neurologic outcome within the first 6 hours after arrest (odds ratio, 1.23; 95% confidence interval, 1.09-1.38) and survival to hospital discharge (odds ratio, 1.20; 95% confidence interval, 1.08-1.34).

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