MedStar Authors catalog › Details for: Scaffold Thrombosis After Percutaneous Coronary Intervention With ABSORB Bioresorbable Vascular Scaffold: A Systematic Review and Meta-Analysis. [Review]

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Scaffold Thrombosis After Percutaneous Coronary Intervention With ABSORB Bioresorbable Vascular Scaffold: A Systematic Review and Meta-Analysis. [Review]

by Lipinski, Michael J; Escarcega, Ricardo O; Baker, Nevin C; Benn, Hadiya A; Gaglia, Michael AJ; Torguson, Rebecca; Waksman, Ron.
Citation: Jacc: Cardiovascular Interventions. 9(1):12-24, 2016 Jan 11..Journal: JACC. Cardiovascular interventions.Published: 2016ISSN: 1936-8798.Full author list: Lipinski MJ; Escarcega RO; Baker NC; Benn HA; Gaglia MA Jr; Torguson R; Waksman R.UI/PMID: 26762906.Subject(s): *Absorbable Implants | Acute Coronary Syndrome/di [Diagnosis] | Acute Coronary Syndrome/mo [Mortality] | *Acute Coronary Syndrome/th [Therapy] | Aged | Angina, Stable/di [Diagnosis] | Angina, Stable/mo [Mortality] | *Angina, Stable/th [Therapy] | Chi-Square Distribution | Coronary Artery Disease/di [Diagnosis] | Coronary Artery Disease/mo [Mortality] | *Coronary Artery Disease/th [Therapy] | Coronary Thrombosis/di [Diagnosis] | *Coronary Thrombosis/et [Etiology] | Coronary Thrombosis/mo [Mortality] | Female | Humans | Male | Middle Aged | Myocardial Infarction/et [Etiology] | Odds Ratio | Percutaneous Coronary Intervention/ae [Adverse Effects] | *Percutaneous Coronary Intervention/is [Instrumentation] | Percutaneous Coronary Intervention/mo [Mortality] | Prosthesis Design | Risk Assessment | Risk Factors | Time Factors | Treatment OutcomeInstitution(s): MedStar Heart & Vascular InstituteActivity type: Journal Article.Medline article type(s): Journal Article | Meta-Analysis | ReviewOnline resources: Click here to access online Digital Object Identifier: http://dx.doi.org/10.1016/j.jcin.2015.09.024 (Click here) Abbreviated citation: JACC Cardiovasc Interv. 9(1):12-24, 2016 Jan 11.Local Holdings: Available online through MWHC library: 2008 - present.Abstract: OBJECTIVES: The aim of this study was to determine the risk of scaffold thrombosis (ST) after percutaneous coronary intervention (PCI) with placement of an ABSORB bioresorbable vascular scaffold (BVS) (Abbott Vascular, Santa Clara, California) by conducting a systematic review and meta-analysis.Abstract: BACKGROUND: PCI with BVS placement holds great potential, but concern has recently been raised regarding the risk of ST.Abstract: METHODS: MEDLINE/PubMed, Cochrane CENTRAL, and meeting abstracts were searched for all studies that included outcomes data for patients after PCI with BVS placement. For studies comparing BVSs with drug-eluting stents (DES), pooled estimates of outcomes, presented as odds ratios (ORs) with 95% confidence intervals (CIs), were generated with random-effects models.Abstract: RESULTS: Our analysis included 10,510 patients (8,351 with a BVS and 2,159 with DES) with a follow-up of 6.4 +/- 5.1 months and 60 +/- 11 years of age; 78% were male, 36% had stable angina, and 59% had acute coronary syndrome (ACS). Among patients with a BVS, cardiovascular death occurred in 0.6%, myocardial infarction (MI) in 2.1%, target lesion revascularization in 2.0%, and definite/probable ST in 1.2% of patients. Of BVS patients, 0.27% had acute ST and 0.57% had subacute ST. Meta-analysis demonstrated that patients who received a BVS were at a higher risk of MI (OR: 2.06, 95% CI: 1.31 to 3.22, p = 0.002) and definite/probable ST (OR: 2.06, 95% CI: 1.07 to 3.98, p = 0.03) compared with patients who received DES, whereas there was a trend toward decreased all-cause mortality with a BVS (OR: 0.40, 95% CI: 0.15 to 1.06, p = 0.06).Abstract: CONCLUSIONS: Patients undergoing PCI with a BVS had increased definite/probable ST and MI during follow-up compared with DES. Further studies with long-term follow-up are needed to assess the risk of ST with a BVS.Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

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