"On-command" dissolvable tympanostomy tube in the chinchilla model: A proof of concept.

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Citation: International Journal of Pediatric Otorhinolaryngology. 101:20-24, 2017 OctPMID: 28964295Institution: MedStar Health Research InstituteForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Hydrogen Peroxide/pd [Pharmacology] | *Middle Ear Ventilation/mt [Methods] | *Tympanic Membrane/su [Surgery] | Animals | Chinchilla | Prospective Studies | Prostheses and ImplantsYear: 2017ISSN:
  • 0165-5876
Name of journal: International journal of pediatric otorhinolaryngologyAbstract: CONCLUSION: Our PBM tubes dissolve "on-command" in a chinchilla model when exposed to treatment with a benign chemical. Dissolvable "on-command" tympanostomy tubes may reduce significant complications related to pediatric tympanostomy tube use. Copyright (c) 2017 Elsevier B.V. All rights reserved.METHODS: Prototype tympanostomy tubes were fabricated from poly(butyl methacrylate-co-(2-dimethylaminoethyl) methacrylate-co- methyl methacrylate) (PBM). "In vitro" dissolution studies were performed with applications of the benign chemical, hydrogen peroxide (HP). PBM tubes were placed into ten chinchilla tympanic membranes matched with standard plastic tubes placed into the contralateral side. All 20 tubes were exposed to HP for 21 days with serial endoscopic examinations. In vitro PBM tubes were weighed before and after interventions and compared to control tubes. In vivo photo documentation was used to show progression of dissolution and histologic slides were obtained to show the effect of the PBM on surrounding tissues.OBJECTIVES: To prove the concept that a dissolvable "on-command" tympanostomy tube placed into the tympanic membrane of a chinchilla can dissolve when a benign solution is applied and result in a well healed tympanic membrane without histologic evidence of injury.RESULTS: Compared to control tubes, all those exposed to hydrogen peroxide had a statistically significant reduction in weight (p < 0.01). After placement into the tympanic membrane of chinchillas, all PBM tubes dissolved within 21 days of hydrogen peroxide treatment leaving behind histologically normal, intact tympanic membranes.STUDY DESIGN: Prospective Randomized Single-Subject Controlled Trial.All authors: Cleary K, Dumont M, Jenkins A, Mai JP, Reilly BK, Wiedermann JPFiscal year: FY2018Digital Object Identifier: Date added to catalog: 2017-10-17
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Journal Article MedStar Authors Catalog Article 28964295 Available 28964295

CONCLUSION: Our PBM tubes dissolve "on-command" in a chinchilla model when exposed to treatment with a benign chemical. Dissolvable "on-command" tympanostomy tubes may reduce significant complications related to pediatric tympanostomy tube use. Copyright (c) 2017 Elsevier B.V. All rights reserved.

METHODS: Prototype tympanostomy tubes were fabricated from poly(butyl methacrylate-co-(2-dimethylaminoethyl) methacrylate-co- methyl methacrylate) (PBM). "In vitro" dissolution studies were performed with applications of the benign chemical, hydrogen peroxide (HP). PBM tubes were placed into ten chinchilla tympanic membranes matched with standard plastic tubes placed into the contralateral side. All 20 tubes were exposed to HP for 21 days with serial endoscopic examinations. In vitro PBM tubes were weighed before and after interventions and compared to control tubes. In vivo photo documentation was used to show progression of dissolution and histologic slides were obtained to show the effect of the PBM on surrounding tissues.

OBJECTIVES: To prove the concept that a dissolvable "on-command" tympanostomy tube placed into the tympanic membrane of a chinchilla can dissolve when a benign solution is applied and result in a well healed tympanic membrane without histologic evidence of injury.

RESULTS: Compared to control tubes, all those exposed to hydrogen peroxide had a statistically significant reduction in weight (p < 0.01). After placement into the tympanic membrane of chinchillas, all PBM tubes dissolved within 21 days of hydrogen peroxide treatment leaving behind histologically normal, intact tympanic membranes.

STUDY DESIGN: Prospective Randomized Single-Subject Controlled Trial.

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