Effect of Low-Intensity Pulsed Ultrasound on Joint Injury and Post-Traumatic Osteoarthritis: an Animal Study.

MedStar author(s):
Citation: Ultrasound in Medicine & Biology. 44(1):234-242, 2018 Jan.PMID: 29111161Institution: MedStar Union Memorial HospitalDepartment: Orthobiologic Laboratory | Orthopaedic SurgeryForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Intra-Articular Fractures/co [Complications] | *Joint Diseases/th [Therapy] | *Osteoarthritis/th [Therapy] | *Ultrasonic Therapy/mt [Methods] | Animals | Disease Models, Animal | Joint Diseases/et [Etiology] | Male | Osteoarthritis/et [Etiology] | Rats | Tibia/in [Injuries] | Treatment Outcome | Ultrasonic WavesYear: 2017ISSN:
  • 0301-5629
Name of journal: Ultrasound in medicine & biologyAbstract: This study investigated the therapeutic potential of low-intensity pulsed ultrasound (LIPUS) in post-traumatic osteoarthritis (PTOA). Intra-articular fracture of the medial tibial plateau was surgically created in 30 rats. LIPUS was applied to the operated joints either for the first 2wk (LIPUS<sub>1-2</sub> group) or in weeks 4 and 5 after intra-articular fracture (LIPUS<sub>4-5</sub> group). In controls, the operated knees were not treated with LIPUS (LIPUS<sub>0</sub> group). The rats were monitored with weekly gait analysis and euthanized at week 8. Among the altered gait parameters, the maximal and average paw print areas in the LIPUS<sub>1-2</sub> and LIPUS<sub>4-5</sub> groups, but not the LIPUS<sub>0</sub> group, had either reached baseline or significantly recovered (70%, p<0.05) by week 8. PTOA pathology in both the LIPUS<sub>1-2</sub> and LIPUS<sub>4-5</sub> groups was less severe than that in the LIPUS<sub>0</sub> group (Mankin score: 5.4 and 4.5 vs. 8.8, p<0.05). In conclusion, LIPUS treatment partially improved the gait of the affected limbs and reduced cartilage degeneration in PTOA. Copyright (c) 2017 World Federation for Ultrasound in Medicine and Biology. Published by Elsevier Inc. All rights reserved.All authors: Bhasin P, Guo Y, Mitchell R, Paudel S, Schon L, Zahoor T, Zhang ZFiscal year: FY2018Digital Object Identifier: Date added to catalog: 2017-12-05
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Journal Article MedStar Authors Catalog Article 29111161 Available 29111161

This study investigated the therapeutic potential of low-intensity pulsed ultrasound (LIPUS) in post-traumatic osteoarthritis (PTOA). Intra-articular fracture of the medial tibial plateau was surgically created in 30 rats. LIPUS was applied to the operated joints either for the first 2wk (LIPUS<sub>1-2</sub> group) or in weeks 4 and 5 after intra-articular fracture (LIPUS<sub>4-5</sub> group). In controls, the operated knees were not treated with LIPUS (LIPUS<sub>0</sub> group). The rats were monitored with weekly gait analysis and euthanized at week 8. Among the altered gait parameters, the maximal and average paw print areas in the LIPUS<sub>1-2</sub> and LIPUS<sub>4-5</sub> groups, but not the LIPUS<sub>0</sub> group, had either reached baseline or significantly recovered (70%, p<0.05) by week 8. PTOA pathology in both the LIPUS<sub>1-2</sub> and LIPUS<sub>4-5</sub> groups was less severe than that in the LIPUS<sub>0</sub> group (Mankin score: 5.4 and 4.5 vs. 8.8, p<0.05). In conclusion, LIPUS treatment partially improved the gait of the affected limbs and reduced cartilage degeneration in PTOA. Copyright (c) 2017 World Federation for Ultrasound in Medicine and Biology. Published by Elsevier Inc. All rights reserved.

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