Scaffold thrombosis following implantation of the ABSORB BVS in routine clinical practice: Insight into possible mechanisms from optical coherence tomography.

MedStar author(s):
Citation: Catheterization & Cardiovascular Interventions. 92(2):E106-E114, 2018 08 01.PMID: 29332307Institution: MedStar Heart & Vascular InstituteForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Absorbable Implants | *Coronary Artery Disease/su [Surgery] | *Coronary Thrombosis/dg [Diagnostic Imaging] | *Coronary Vessels/su [Surgery] | *Percutaneous Coronary Intervention/is [Instrumentation] | *Tomography, Optical Coherence | Aged | Aged, 80 and over | Coronary Angiography | Coronary Artery Disease/dg [Diagnostic Imaging] | Coronary Thrombosis/et [Etiology] | Coronary Vessels/de [Drug Effects] | Female | Humans | Male | Middle Aged | Netherlands | Percutaneous Coronary Intervention/ae [Adverse Effects] | Predictive Value of Tests | Prosthesis Design | Time Factors | Treatment OutcomeYear: 2018Local holdings: Available online from MWHC library: 1996 - present, Available in print through MWHC library: 1996 - 2006ISSN:
  • 1522-1946
Name of journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & InterventionsAbstract: BACKGROUND: The absorb scaffold is associated with an increased risk of ScT compared with metallic stents. Several potential causes of bioresorbable ScT have been identified, however the precise etiology still remains unclear.CONCLUSIONS: OCT performed in patients presenting with Absorb ScT demonstrated that malapposition of scaffold struts was more prominent in patients presenting with (very) late ScT, while underexpansion was more frequent in the early cases.Copyright (c) 2018 Wiley Periodicals, Inc.METHODS: Between February 2013 and February 2016, 13 patients presenting with definite ScT underwent OCT imaging. After guidewire passage or balloon inflations, OCT images were acquired. Pullbacks were assessed offline at each 1 mm longitudinal interval within the treated segment and the 5 mm segments adjacent to both edges. Primary cause of ScT was assessed by reviewing medical records, baseline angiographic films, and OCT pullback and angiographic films at time of ScT.OBJECTIVES: To identify potential underlying mechanisms of early and (very) late scaffold thrombosis (ScT) by optical coherence tomography (OCT), in a frame-by-frame analysis.RESULTS: 13 patients, with 14 thrombotic lesions presented either with early ScT (i.e., <=30 days) or very (late) (i.e., >30 days). Analysis demonstrated a significantly smaller in-scaffold maximal lumen diameter in the early cases (2.75 +/- 0.85 mm vs. 3.00 +/- 0.46 mm; P = 0.033) and a nonsignificant smaller minimal scaffold diameter (2.44 +/- 0.62 mm vs. 2.58 +/- 0.37 mm P = 0.097). Per-strut analysis demonstrated significantly more malapposed scaffold struts in (very) late cases (6% versus 0.6%, P < 0.001). Assessment of the predominate cause showed underexpansion as the dominant factor in the early cases, while malapposition was predominantly seen in the (very)late cases.All authors: Arkenbout EK, de Winter RJ, Garcia-Garcia HM, Henriques JPS, Kajita AH, Kraak RP, Piek JJ, Tijssen JGP, van der Schaaf RJ, Wykrzykowska JJFiscal year: FY2019Fiscal year of original publication: FY2018Digital Object Identifier: Date added to catalog: 2018-01-22
Holdings
Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 29332307 Available 29332307

Available online from MWHC library: 1996 - present, Available in print through MWHC library: 1996 - 2006

BACKGROUND: The absorb scaffold is associated with an increased risk of ScT compared with metallic stents. Several potential causes of bioresorbable ScT have been identified, however the precise etiology still remains unclear.

CONCLUSIONS: OCT performed in patients presenting with Absorb ScT demonstrated that malapposition of scaffold struts was more prominent in patients presenting with (very) late ScT, while underexpansion was more frequent in the early cases.

Copyright (c) 2018 Wiley Periodicals, Inc.

METHODS: Between February 2013 and February 2016, 13 patients presenting with definite ScT underwent OCT imaging. After guidewire passage or balloon inflations, OCT images were acquired. Pullbacks were assessed offline at each 1 mm longitudinal interval within the treated segment and the 5 mm segments adjacent to both edges. Primary cause of ScT was assessed by reviewing medical records, baseline angiographic films, and OCT pullback and angiographic films at time of ScT.

OBJECTIVES: To identify potential underlying mechanisms of early and (very) late scaffold thrombosis (ScT) by optical coherence tomography (OCT), in a frame-by-frame analysis.

RESULTS: 13 patients, with 14 thrombotic lesions presented either with early ScT (i.e., <=30 days) or very (late) (i.e., >30 days). Analysis demonstrated a significantly smaller in-scaffold maximal lumen diameter in the early cases (2.75 +/- 0.85 mm vs. 3.00 +/- 0.46 mm; P = 0.033) and a nonsignificant smaller minimal scaffold diameter (2.44 +/- 0.62 mm vs. 2.58 +/- 0.37 mm P = 0.097). Per-strut analysis demonstrated significantly more malapposed scaffold struts in (very) late cases (6% versus 0.6%, P < 0.001). Assessment of the predominate cause showed underexpansion as the dominant factor in the early cases, while malapposition was predominantly seen in the (very)late cases.

English

Powered by Koha