MedStar Authors catalog › Details for: Serial volumetric assessment of coronary fibroatheroma by optical frequency domain imaging: insights from the TROFI trial.
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Serial volumetric assessment of coronary fibroatheroma by optical frequency domain imaging: insights from the TROFI trial.

by Garcia-Garcia, Hector M.
Citation: European heart journal cardiovascular Imaging. 19(1):92-100, 2018 01 01..Journal: European heart journal cardiovascular Imaging.Published: ; 2017ISSN: 2047-2404.Full author list: Campos CM; Garcia-Garcia HM; Iqbal J; Muramatsu T; Nakatani S; Dijkstra J; Onuma Y; Serruys PW.UI/PMID: 28200140.Subject(s): Aged | Combined Modality Therapy | *Coronary Artery Disease/dg [Diagnostic Imaging] | Coronary Artery Disease/th [Therapy] | Female | Follow-Up Studies | Humans | Male | Middle Aged | Percutaneous Coronary Intervention | *Plaque, Atherosclerotic/dg [Diagnostic Imaging] | Plaque, Atherosclerotic/su [Surgery] | Prospective Studies | Risk Assessment | ST Elevation Myocardial Infarction/dg [Diagnostic Imaging] | ST Elevation Myocardial Infarction/mo [Mortality] | *ST Elevation Myocardial Infarction/th [Therapy] | Survival Rate | *Thrombectomy/mt [Methods] | Time Factors | *Tomography, Optical Coherence/mt [Methods] | Treatment OutcomeInstitution(s): MedStar Heart & Vascular InstituteActivity type: Journal Article.Medline article type(s): Journal ArticleDigital Object Identifier: https://dx.doi.org/10.1093/ehjci/jew338 (Click here) Abbreviated citation: Eur Heart J Cardiovasc Imaging. 19(1):92-100, 2018 01 01.Abstract: Aims: Coronary lesions precursors of acute events remain elusive, since they undergo continuous changes and their temporal changes are not very well-characterized. In natural history studies, optical frequency domain imaging (OFDI) has been used only to assess fibroatheromas as a 2D structure and sometimes in a single frame fashion. We aim at describing the serial volumetric modifications of the fibrous cap (FC) of the fibroatheromas as determined by OFDI over a 6-month follow-up period.Abstract: Methods and results: In 49 patients, OFDI investigation was performed following treatment of culprit lesion and at 6-month follow-up in patients with ST-segment elevation myocardial infarction (STEMI). A fully automatic volumetric quantification of FC was done in all lipid-containing frames of non-culprit lesions in the infarct related artery. These lesions were matched at baseline and 6-month follow-up. A total of 58 non-culprit lipid rich lesions (34 TCFAs and 24 thick-cap fibroatheroma [ThCFA]) were found in 34 patients at baseline. Overall, there was a FC volume decrease of 1.57 (Inter-quartile Range [IQR] -4.13 to 0.54) mm3 at 6-months. 27% of the lesions changed their phenotype over time (TCFA or ThCFA). TCFAs that became ThCFAs at follow-up had smaller mean and maximal FC as compared with lesions that remained TCFAs (P = 0.01 for both).Abstract: Conclusions: Non-culprit fibroatheromas located in the infarct related artery of patients with STEMI had a volumetric reduction of the FC after 6-month follow-up. Quantitative FC assessment was able to differentiate high-risk lesions that became ThCFAs. There was a considerable change of plaque phenotype (TCFAs or ThCFAs) over time.Abstract: Copyright Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2017. For permissions, please email: [email protected]

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