MedStar Authors catalog › Details for: Comparison in Men Versus Women of Co-morbidities, Complications, and Outcomes After Transcatheter Aortic Valve Implantation for Severe Aortic Stenosis.
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Comparison in Men Versus Women of Co-morbidities, Complications, and Outcomes After Transcatheter Aortic Valve Implantation for Severe Aortic Stenosis.

by Gaglia, Michael AJ; Lipinski, Michael J; Torguson, Rebecca; Gai, Jiaxiang; Ben-Dor, Itsik; Bernardo, Nelson L; Satler, Lowell F; Pichard, Augusto D; Waksman, Ron.
Citation: American Journal of Cardiology. 118(11):1692-1697, 2016 Dec 01.Journal: The American journal of cardiology.Published: 2016ISSN: 0002-9149.Full author list: Gaglia MA Jr; Lipinski MJ; Torguson R; Gai J; Ben-Dor I; Bernardo NL; Satler LF; Pichard AD; Waksman R.UI/PMID: 27666174.Subject(s): Aged, 80 and over | Aortic Valve Stenosis/di [Diagnosis] | Aortic Valve Stenosis/ep [Epidemiology] | *Aortic Valve Stenosis/su [Surgery] | Cause of Death/td [Trends] | Comorbidity | *Coronary Artery Disease/ep [Epidemiology] | District of Columbia/ep [Epidemiology] | Female | Follow-Up Studies | Humans | Male | *Postoperative Complications/ep [Epidemiology] | Retrospective Studies | *Risk Assessment | Risk Factors | Severity of Illness Index | Sex Distribution | Survival Rate/td [Trends] | Time Factors | *Transcatheter Aortic Valve Replacement/ae [Adverse Effects]Institution(s): MedStar Health Research InstituteActivity type: Journal Article.Medline article type(s): Journal ArticleOnline resources: Click here to access online Digital Object Identifier: (Click here) Abbreviated citation: Am J Cardiol. 118(11):1692-1697, 2016 Dec 01.Local Holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006.Abstract: Transcatheter aortic valve implantation (TAVI) decreases mortality in high-risk patients with severe aortic stenosis, but it remains unclear if female gender is associated with more favorable outcomes after TAVI. All patients who underwent TAVI at a single institution were retrospectively analyzed and stratified by gender. Procedural, in-hospital, 30-day, and 1-year outcomes were defined according to the second Valve Academic Research Consortium. The primary end point was all-cause mortality at 1 year. Kaplan-Meier survival analysis and multivariable Cox proportional hazards regression were conducted. Overall, 755 patients underwent TAVI and were included in the study; 50.7% were women. Average age was 83.0 +/- 7.7 years, with a mean Society of Thoracic Surgeons score of 8.9 +/- 4.6. Women were older than men and more likely to be black. Most co-morbidities were less common among women, and they were more likely than men to suffer both in-hospital (8.4% vs 4.3%, p = 0.021) and 30-day (9.4% vs 5.4%, p = 0.035) all-cause mortality. Life-threatening bleeding, transfusion, and iliofemoral dissection or perforation were more common among women. There was no difference in mortality between women and men at 1 year (20.6% vs 21.5%, log-rank p = 0.87). After multivariable adjustment, however, female gender was independently associated with lower mortality at 1 year after TAVI. In conclusion, despite higher rates of major bleeding, vascular complications, and 30-day mortality, female gender was independently associated with improved survival at 1 year after TAVI.Abstract: Copyright � 2016 Elsevier Inc. All rights reserved.

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