Citation: American Heart Journal. 178:19-27, 2016 Aug.Journal: American heart journal.Published: 2016ISSN: 0002-8703.Full author list: Kiramijyan S; Magalhaes MA; Koifman E; Didier R; Escarcega RO; Minha S; Baker NC; Negi SI; Torguson R; Gai J; Okubagzi P; Asch FM; Gaglia MA Jr; Ben-Dor I; Satler LF; Pichard AD; Waksman R.UI/PMID: 27502848.Subject(s): Aged | Aged, 80 and over | Aortic Valve Stenosis/dg [Diagnostic Imaging] | Aortic Valve Stenosis/ep [Epidemiology] | *Aortic Valve Stenosis/su [Surgery] | Cohort Studies | Comorbidity | Databases, Factual | Echocardiography | Female | Humans | Male | Mitral Valve Insufficiency/dg [Diagnostic Imaging] | *Mitral Valve Insufficiency/ep [Epidemiology] | Mortality | Prognosis | Proportional Hazards Models | Retrospective Studies | Severity of Illness Index | Survival Analysis | *Transcatheter Aortic Valve Replacement | Treatment OutcomeInstitution(s): MedStar Heart & Vascular InstituteActivity type: Journal Article.Medline article type(s): Journal ArticleOnline resources: Click here to access onlineDigital Object Identifier: https://dx.doi.org/10.1016/j.ahj.2016.03.020 (Click here)Abbreviated citation: Am Heart J. 178:19-27, 2016 Aug.Local Holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006.Abstract: BACKGROUND: The prevalence of concomitant significant mitral regurgitation (MR) in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) ranges from 2% to 33%. The impact of significant MR on post-TAVR outcomes remains controversial.Abstract: METHODS: The data from a cohort of patients with symptomatic severe AS undergoing TAVR at out institution were retrospectively analyzed. The last transthoracic echocardiogram (TTE) before the index TAVR procedure was selected as the baseline assessment of the degree of MR. The total study cohort (N = 589) was divided into 2 groups: significant >moderate MR (n = 68) versus nonsignificant <moderate MR (n = 521) at baseline. The 2 groups were compared in regard to baseline, imaging, procedural, and postprocedural characteristics. In-hospital, 30-day, and 1-year outcomes were assessed. Multivariate Cox regression survival analyses were performed to test the independent effect of >moderate MR on mortality at short- and long-term follow-up periods.Abstract: RESULTS: Patients with >moderate MR had a higher mortality rate versus patients with <moderate MR during the initial 30-day follow-up after TAVR (unadjusted log-rank P = .011, risk-adjusted P = .031, hazard ratio = 2.40, 95% CI 1.08-5.29). However, the mortality rates at 1-year follow-up postprocedure were similar between the 2 groups (unadjusted log-rank P = .553, risk-adjusted P = .331, hazard ratio = 0.70, 95% CI 0.35-1.43). Among the original >moderate group, 62.5% and 77.7% of patients had improved to <moderate MR at 30-day and 1-year follow-up, respectively.Abstract: CONCLUSIONS: Moderate or greater MR in patients undergoing TAVR is associated with a higher 30-day but not 1-year mortality. A majority of the patients demonstrated significant improvement in MR following TAVR.Abstract: Copyright � 2016. Published by Elsevier Inc.