Human Papillomavirus Prevalence Among American Indian Women of the Great Plains.

MedStar author(s):
Citation: Journal of Infectious Diseases. 219(6):908-915, 2019 02 23.PMID: 30321371Institution: MedStar Health Research InstituteForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Indians, North American | *Papillomaviridae/ip [Isolation & Purification] | *Papillomavirus Infections/ep [Epidemiology] | Adult | Aged | Female | Genotype | Humans | Middle Aged | Midwestern United States/ep [Epidemiology] | Papillomaviridae/ge [Genetics] | Papillomavirus Infections/eh [Ethnology] | Papillomavirus Infections/vi [Virology] | PrevalenceYear: 2019Local holdings: Available online from MWHC library: April 1997 - present, Available in print through MWHC library: 1999 - presentISSN:
  • 0022-1899
Name of journal: The Journal of infectious diseasesAbstract: Background: High-risk human papillomavirus (HrHPV) causes cervical cancer. In the U.S., approximately 40% of women aged 14-59 years from all racial and ethnic groups are infected with HPV, and prevalence typically declines with age. However, American Indian women are insufficiently sampled to permit a population-specific estimate of HrHPV prevalence.Conclusion: HPV-51 was the single most prevalent oncogenic genotype. The combined prevalence of HrHPV among AI women in our sample was high, particularly among women aged 50-65 years, for whom HrHPV prevalence was approximately triple that of other races. Cervical cancer screening efforts should be increased particularly among women from the community aged 30 years and older.Methods: Vaginal swabs were self-collected by 698 AI women aged 21-65 years from a tribal community in the Great Plains. We estimated the population prevalence of HrHPV and identified predominant genotypes.Results: The combined prevalence of HrHPV genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 was 34.8%. HPV-51 (7.6%), HPV-58 (5.3%), HPV-52 (4.3%), HPV-18 (4.3%), and HPV-16 (3.9%) were most prevalent. HrHPV prevalence declined with age, from 42.2% in women aged 21-24 years to 27.9% in women aged 50-65 years.All authors: Buchwald D, Cherne S, Collaborative to Improve Native Cancer Outcomes (CINCO), Gonzales AA, Lee NR, Nelson L, Noonan CJ, Umans JG, Winer RLFiscal year: FY2019Digital Object Identifier: Date added to catalog: 2018-11-02
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Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 30321371 Available 30321371

Available online from MWHC library: April 1997 - present, Available in print through MWHC library: 1999 - present

Background: High-risk human papillomavirus (HrHPV) causes cervical cancer. In the U.S., approximately 40% of women aged 14-59 years from all racial and ethnic groups are infected with HPV, and prevalence typically declines with age. However, American Indian women are insufficiently sampled to permit a population-specific estimate of HrHPV prevalence.

Conclusion: HPV-51 was the single most prevalent oncogenic genotype. The combined prevalence of HrHPV among AI women in our sample was high, particularly among women aged 50-65 years, for whom HrHPV prevalence was approximately triple that of other races. Cervical cancer screening efforts should be increased particularly among women from the community aged 30 years and older.

Methods: Vaginal swabs were self-collected by 698 AI women aged 21-65 years from a tribal community in the Great Plains. We estimated the population prevalence of HrHPV and identified predominant genotypes.

Results: The combined prevalence of HrHPV genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 was 34.8%. HPV-51 (7.6%), HPV-58 (5.3%), HPV-52 (4.3%), HPV-18 (4.3%), and HPV-16 (3.9%) were most prevalent. HrHPV prevalence declined with age, from 42.2% in women aged 21-24 years to 27.9% in women aged 50-65 years.

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