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In Vivo Formation and Tracking of pi-Peptide Nanostructures. [Review]

MedStar author(s):

Citation: Acs Applied Materials & Interfaces. 15(21):25091-25097, 2023 May 31.PMID: 35838681Institution: MedStar Franklin Square Medical CenterForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: IN PROCESS -- NOT YET INDEXEDYear: 2022 ISSN:

1944-8244

Name of journal: ACS applied materials & interfacesAbstract: The photophysics associated with the self-assembly of pi-peptide molecules into 1-D nanostructures has been well-established, thus revealing the creation of nanoscale electronic conduits in aqueous media. Such materials have therapeutic potential in many biomedical applications. In this work, we report the in vivo deployment of these pi-peptide nanostructures in brain tissue using photothrombotic stroke as a model application. A test peptide was used for brain injections, and the nanostructures formed were visualized with electron microscopy. A new peptide bearing a low-energy fluorescence dye was prepared to facilitate direct visualization of pi-peptide localization in the brain cavity by way of fluorescence microscopy. This work demonstrates feasibility for in vivo application of pi-peptide nanostructures toward pressing biomedical challenges.All authors: Deboer SR, Dibble JP, Felling RJ, Mersha M, Robinson TJ, Tovar JD, Zeiler SRFiscal year: FY2023 Digital Object Identifier:

https://dx.doi.org/10.1021/acsami.2c04598

Date added to catalog: 2022-09-26

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Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	35838681	Available		35838681

The photophysics associated with the self-assembly of pi-peptide molecules into 1-D nanostructures has been well-established, thus revealing the creation of nanoscale electronic conduits in aqueous media. Such materials have therapeutic potential in many biomedical applications. In this work, we report the in vivo deployment of these pi-peptide nanostructures in brain tissue using photothrombotic stroke as a model application. A test peptide was used for brain injections, and the nanostructures formed were visualized with electron microscopy. A new peptide bearing a low-energy fluorescence dye was prepared to facilitate direct visualization of pi-peptide localization in the brain cavity by way of fluorescence microscopy. This work demonstrates feasibility for in vivo application of pi-peptide nanostructures toward pressing biomedical challenges.

English