Intralesional Cidofovir for Treatment of Acyclovir-Resistant Laryngeal Herpes Manifesting as Supraglottic Mass.

MedStar author(s):
Citation: Annals of Otology, Rhinology & Laryngology. :3489418818579, 2018 Dec 17PMID: 30556399Institution: MedStar Washington Hospital CenterDepartment: Medicine/Infectious DiseasesForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: IN PROCESS -- NOT YET INDEXEDYear: 2018Local holdings: Available online from MWHC library: 1998 - 2008, Available in print through MWHC library: 1999 - 2008ISSN:
  • 0003-4894
Name of journal: The Annals of otology, rhinology, and laryngologyAbstract: CASE PRESENTATION:: We report a case of bulky, obstructive supraglottic and glottic herpes virus laryngitis that presented with dysphonia, dysphagia, and airway complaints resistant to acyclovir analogues that was treated effectively with intralesional cidofovir injection.CONCLUSIONS:: Our promising initial response suggests a potential novel treatment for this unusual condition.INTRODUCTION:: Laryngopharyngeal herpes simplex virus infection is rare and presents typically in the supraglottis. Findings on presentation can range from small mucosal lesions to fungating obstructive masses mimicking neoplasm. Laryngopharyngeal herpes is a medically treated disease.METHODS:: Individual case with treatment adapted from other case report.OBJECTIVES:: Identify potential treatment in cases that are refractory to antiviral medications.All authors: Dhillon VK, Kumar PN, Mathur A, Yang CQFiscal year: FY2019Digital Object Identifier: Date added to catalog: 2019-01-08
Holdings
Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 30556399 Available 30556399

Available online from MWHC library: 1998 - 2008, Available in print through MWHC library: 1999 - 2008

CASE PRESENTATION:: We report a case of bulky, obstructive supraglottic and glottic herpes virus laryngitis that presented with dysphonia, dysphagia, and airway complaints resistant to acyclovir analogues that was treated effectively with intralesional cidofovir injection.

CONCLUSIONS:: Our promising initial response suggests a potential novel treatment for this unusual condition.

INTRODUCTION:: Laryngopharyngeal herpes simplex virus infection is rare and presents typically in the supraglottis. Findings on presentation can range from small mucosal lesions to fungating obstructive masses mimicking neoplasm. Laryngopharyngeal herpes is a medically treated disease.

METHODS:: Individual case with treatment adapted from other case report.

OBJECTIVES:: Identify potential treatment in cases that are refractory to antiviral medications.

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