MedStar Authors catalog › Details for: A gene-family analysis of 61 genetic variants in the nicotinic acetylcholine receptor genes for insulin resistance and type 2 diabetes in American Indians.
A gene-family analysis of 61 genetic variants in the nicotinic acetylcholine receptor genes for insulin resistance and type 2 diabetes in American Indians. Journal: Diabetes.ISSN: 0012-1797.UI/PMID: 22586585.Subject(s): Adult | Aged | Blood Glucose/an [Analysis] | Diabetes Mellitus, Type 2/ep [Epidemiology] | *Diabetes Mellitus, Type 2/ge [Genetics] | Female | Genetic Association Studies/sn [Statistics & Numerical Data] | Genetic Predisposition to Disease | *Genetic Variation | Humans | *Indians, North American/ge [Genetics] | Insulin/bl [Blood] | *Insulin Resistance/ge [Genetics] | Male | Middle Aged | Pedigree | Polymorphism, Single Nucleotide | *Receptors, Nicotinic/ge [Genetics] | Smoking/ep [Epidemiology] | Smoking/ge [Genetics] | Young AdultInstitution(s): MedStar Health Research InstituteActivity type: Journal Article.Medline article type(s): Journal Article | Research Support, N.I.H., ExtramuralOnline resources: Click here to access online Digital Object Identifier: http://dx.doi.org/10.2337/db11-1393 (Click here) Abbreviated citation: Diabetes. 61(7):1888-94, 2012 Jul.Local Holdings: Available online from MWHC library: 1995 - present (after 3 months), Available in print through MWHC library: 1999 - 2006.Abstract: Cigarette smoking is a risk factor for type 2 diabetes. Genetic variants in the nicotinic acetylcholine receptor (nAChR) genes have been associated with smoking phenotypes and are likely to influence diabetes. Although each single variant may have only a minor effect, the joint contribution of multiple single nucleotide polymorphisms (SNPs) to the occurrence of disease may be larger. In this study, we conducted a gene-family analysis to investigate the joint impact of 61 tag SNPs in 7 nAChRs genes on insulin resistance and type 2 diabetes in 3,665 American Indians recruited by the Strong Heart Family Study. Results show that although multiple SNPs showed marginal individual association with insulin resistance and type 2 diabetes, only a few can pass adjustment for multiple testing. However, a gene-family analysis considering the joint impact of all 61 SNPs reveals significant association of the nAChR gene family with both insulin resistance and type 2 diabetes (both P < 0.0001), suggesting that genetic variants in the nAChR genes jointly contribute to insulin resistance and type 2 diabetes among American Indians. The effects of these genetic variants on insulin resistance and diabetes are independent of cigarette smoking per se.