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Respiratory and Hemodynamic Changes in Neonates with Hypoxic-Ischemic Encephalopathy during and after Whole-Body Hypothermia.

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Citation: American Journal of Perinatology. 38(1):37-43, 2021 01.PMID: 31412405Institution: MedStar Heart & Vascular InstituteForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Hemodynamics | *Hypothermia, Induced | *Hypoxia-Ischemia, Brain/pp [Physiopathology] | *Respiration | Humans | Hypoxia-Ischemia, Brain/th [Therapy] | Infant, Newborn | Linear Models | Oxygen Consumption/ph [Physiology] | Oxygen/bl [Blood] | Retrospective StudiesYear: 2021 ISSN:

0735-1631

Name of journal: American journal of perinatologyAbstract: CONCLUSION: There was a decrease in metabolic demand as measured by oxygen requirement, OI, HR, and MBP during WBH, but only HR increased during rewarming, with no significant change in the other parameters. Some of this effect may be explained by improvement in the respiratory condition over time.Copyright Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.OBJECTIVE: To determine the degree to which whole-body hypothermia (WBH) impacts hemodynamic and respiratory status during hypothermia and the subsequent rewarming period in neonates with hypoxic-ischemic encephalopathy (HIE).RESULTS: HR decreased during WBH and significantly increased during rewarming. Lactate level, OI, VEI, FiO2, and MBP all decreased during WBH but showed no significant change during and after rewarming.STUDY DESIGN: This is a retrospective study reviewing the medical records of infants treated with WBH. Data including oxygenation index (OI), ventilator efficiency index (VEI), fraction of inspired oxygen (FiO2), blood lactate level, heart rate (HR), and mean blood pressure (MBP) were collected from defined time points from the beginning, middle, and end of WBH and then every 2 hours from the beginning of rewarming for 14 hours thereafter. The analysis included 65 infants. Data were analyzed using a piecewise linear regression with a mixed-effect model.All authors: Abubakar K, Desale S, Sheppard SROriginally published: American Journal of Perinatology. 2019 Aug 14Fiscal year: FY2021Fiscal year of original publication: FY2020Digital Object Identifier:

https://dx.doi.org/10.1055/s-0039-1694730

Date added to catalog: 2019-08-27

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Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	31412405	Available		31412405

CONCLUSION: There was a decrease in metabolic demand as measured by oxygen requirement, OI, HR, and MBP during WBH, but only HR increased during rewarming, with no significant change in the other parameters. Some of this effect may be explained by improvement in the respiratory condition over time.

OBJECTIVE: To determine the degree to which whole-body hypothermia (WBH) impacts hemodynamic and respiratory status during hypothermia and the subsequent rewarming period in neonates with hypoxic-ischemic encephalopathy (HIE).

RESULTS: HR decreased during WBH and significantly increased during rewarming. Lactate level, OI, VEI, FiO2, and MBP all decreased during WBH but showed no significant change during and after rewarming.

STUDY DESIGN: This is a retrospective study reviewing the medical records of infants treated with WBH. Data including oxygenation index (OI), ventilator efficiency index (VEI), fraction of inspired oxygen (FiO2), blood lactate level, heart rate (HR), and mean blood pressure (MBP) were collected from defined time points from the beginning, middle, and end of WBH and then every 2 hours from the beginning of rewarming for 14 hours thereafter. The analysis included 65 infants. Data were analyzed using a piecewise linear regression with a mixed-effect model.

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