Microbleed prevalence and burden in anticoagulant-associated intracerebral bleed.

MedStar author(s):
Citation: Annals of Clinical & Translational Neurology. 6(8):1546-1551, 2019 08.PMID: 31402613Institution: MedStar Washington Hospital CenterDepartment: Surgical Critical CareForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Anticoagulants/tu [Therapeutic Use] | *Cerebral Hemorrhage/dt [Drug Therapy] | *Vitamin K/tu [Therapeutic Use] | Administration, Oral | Aged | Aged, 80 and over | Cohort Studies | Female | Humans | Male | Middle Aged | Prevalence | Retrospective Studies | Stroke | Vitamin K/ai [Antagonists & Inhibitors]Year: 2019ISSN:
  • 2328-9503
Name of journal: Annals of clinical and translational neurologyAbstract: Copyright (c) 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.Prior studies suggest an association between Vitamin K antagonists (VKA) and cerebral microbleeds (CMBs); less is known about nonvitamin K oral anticoagulants (NOACs). In this observational study we describe CMB profiles in a multicenter cohort of 89 anticoagulation-related intracerebral hemorrhage (ICH) patients. CMB prevalence was 51% (52% in VKA-ICH, 48% in NOAC-ICH). NOAC-ICH patients had lower median CMB count [2(IQR:1-3) vs. 7(4-11); P < 0.001]; >=5 CMBs were less prevalent in NOAC-ICH (4% vs. 31%, P = 0.006). This inverse association between NOAC exposure and high CMB count persisted in multivariable logistic regression models adjusting for potential confounders (OR 0.10, 95%CI: 0.01-0.83; P = 0.034).All authors: Alexandrov AV, Boviatsis E, Chang J, Goyal N, Kargiotis O, Katsanos AH, Krogias C, Lioutas VA, Malhotra K, Mehta C, Mitsias PD, Paciaroni M, Pandhi A, Schroeder C, Selim MH, Sharaf A, Sharma VK, Tsantes A, Tsivgoulis G, Varelas P, Zand ROriginally published: Annals of Clinical & Translational Neurology. 6(8):1546-1551, 2019 Aug.Fiscal year: FY2020Digital Object Identifier: Date added to catalog: 2019-08-27
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Journal Article MedStar Authors Catalog Article 31402613 Available 31402613

Copyright (c) 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

Prior studies suggest an association between Vitamin K antagonists (VKA) and cerebral microbleeds (CMBs); less is known about nonvitamin K oral anticoagulants (NOACs). In this observational study we describe CMB profiles in a multicenter cohort of 89 anticoagulation-related intracerebral hemorrhage (ICH) patients. CMB prevalence was 51% (52% in VKA-ICH, 48% in NOAC-ICH). NOAC-ICH patients had lower median CMB count [2(IQR:1-3) vs. 7(4-11); P < 0.001]; >=5 CMBs were less prevalent in NOAC-ICH (4% vs. 31%, P = 0.006). This inverse association between NOAC exposure and high CMB count persisted in multivariable logistic regression models adjusting for potential confounders (OR 0.10, 95%CI: 0.01-0.83; P = 0.034).

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