I-124 PET/CT versus conventional radioiodine imaging in differentiated thyroid cancer: a review.

MedStar author(s):
Citation: Thyroid. 29(11):1523-1535, 2019 11.PMID: 31452449Institution: MedStar Health Research Institute | MedStar Washington Hospital CenterDepartment: Library | Medicine/Endocrinology | Medicine/Nuclear MedicineForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Iodine Radioisotopes | *Positron Emission Tomography Computed Tomography/mt [Methods] | *Radiopharmaceuticals | *Thyroid Neoplasms/dg [Diagnostic Imaging] | *Tomography, X-Ray Computed/mt [Methods] | HumansYear: 2019Local holdings: Available online from MWHC library: August 2000 - present, Available in print through MWHC library: 1999 - 2006ISSN:
  • 1050-7256
Name of journal: Thyroid : official journal of the American Thyroid AssociationAbstract: BACKGROUND: Studies report a wide spectrum of I-124 PET/CT sensitivity and specificity in detection of differentiated thyroid cancer (DTC) lesions. This paper reviews the lesion detection rate of pretherapy I-124 PET/CT in different patient populations and further analyzes the factors for better detection on I-124 PET/CT.CONCLUSION: I-124 PET/CT is able to identify a greater number of foci compared to diagnostic I-131 scan. I-124 PET may have better detection compared to posttherapy I-131 scan in patients who are I-131 therapy naive, have less aggressive pathology or do not have disseminated lung metastases. Additional metastatic lesion detection by I-124 PET has significant clinical impact in the management of patients prior to I-131 therapy in some patients.METHODS: A literature search was performed using multiple different databases from 1996 to April 2018. Searches include MEDLINE, EMBASE, Northern Lights and handsearching. Two reviewers reviewed and extracted study data for I-124, I-123 and I-131 scans in DTC.RESULTS: This review includes four retrospective and ten prospective studies in which 495 DTC patients underwent I-124 and I-131 imaging; no studies made comparisons to I-123. In the reports that compared I-124 to diagnostic I-131scan, there were a total of 72 patients in whom120 lesions were detected on I-124 whereas only 52 were detected on diagnostic I-131 scan; in publications that compared I-124 to posttherapy I-131scan in 266 patients, 410 lesions were detected on I-124 whereas 390 were detected on posttherapy I-131 scan. Based on I-124 PET/CT in six studies, TNM staging was revised in 15-21% of patients and disease management was altered in 5-29% of patients.All authors: Burman KD, Heimlich SL, Van Nostrand D, Wartofsky L, Wu D, Ylli DOriginally published: Thyroid. 2019 Aug 27Fiscal year: FY2020Original title: 124I Positron Emission Tomography/Computed Tomography Versus Conventional Radioiodine Imaging in Differentiated Thyroid Cancer: A Review. [Review]Digital Object Identifier: Date added to catalog: 2019-10-10
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Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 31452449 Available 31452449

Available online from MWHC library: August 2000 - present, Available in print through MWHC library: 1999 - 2006

BACKGROUND: Studies report a wide spectrum of I-124 PET/CT sensitivity and specificity in detection of differentiated thyroid cancer (DTC) lesions. This paper reviews the lesion detection rate of pretherapy I-124 PET/CT in different patient populations and further analyzes the factors for better detection on I-124 PET/CT.

CONCLUSION: I-124 PET/CT is able to identify a greater number of foci compared to diagnostic I-131 scan. I-124 PET may have better detection compared to posttherapy I-131 scan in patients who are I-131 therapy naive, have less aggressive pathology or do not have disseminated lung metastases. Additional metastatic lesion detection by I-124 PET has significant clinical impact in the management of patients prior to I-131 therapy in some patients.

METHODS: A literature search was performed using multiple different databases from 1996 to April 2018. Searches include MEDLINE, EMBASE, Northern Lights and handsearching. Two reviewers reviewed and extracted study data for I-124, I-123 and I-131 scans in DTC.

RESULTS: This review includes four retrospective and ten prospective studies in which 495 DTC patients underwent I-124 and I-131 imaging; no studies made comparisons to I-123. In the reports that compared I-124 to diagnostic I-131scan, there were a total of 72 patients in whom120 lesions were detected on I-124 whereas only 52 were detected on diagnostic I-131 scan; in publications that compared I-124 to posttherapy I-131scan in 266 patients, 410 lesions were detected on I-124 whereas 390 were detected on posttherapy I-131 scan. Based on I-124 PET/CT in six studies, TNM staging was revised in 15-21% of patients and disease management was altered in 5-29% of patients.

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