MedStar Authors catalog › Details for: Clinical outcomes of complete revascularization using either angiography-guided or fractional flow reserve-guided drug-eluting stent implantation in non-culprit vessels in ST elevation myocardial infarction patients: insights from a study based on a systematic review and meta-analysis. [Review]
Clinical outcomes of complete revascularization using either angiography-guided or fractional flow reserve-guided drug-eluting stent implantation in non-culprit vessels in ST elevation myocardial infarction patients: insights from a study based on a systematic review and meta-analysis. [Review] Journal: The international journal of cardiovascular imaging. Published: 2018 ISSN: 1569-5794. UI/PMID: 29779179. Subject(s): Coronary Angiography | Coronary Artery Disease/co [Complications] | Coronary Artery Disease/dg [Diagnostic Imaging] | Coronary Artery Disease/pp [Physiopathology] | *Coronary Artery Disease/th [Therapy] | *Drug-Eluting Stents | Fractional Flow Reserve, Myocardial | Humans | *Myocardial Revascularization/mt [Methods] | *Percutaneous Coronary Intervention | ST Elevation Myocardial Infarction/dg [Diagnostic Imaging] | ST Elevation Myocardial Infarction/et [Etiology] | ST Elevation Myocardial Infarction/pp [Physiopathology] | *ST Elevation Myocardial Infarction/th [Therapy] | Treatment Outcome Institution(s): MedStar Heart & Vascular Institute Activity type: Journal Article. Medline article type(s): Journal Article | Review Digital Object Identifier: https://dx.doi.org/10.1007/s10554-018-1362-9 (Click here) Abbreviated citation: Int J Cardiovasc Imaging. 34(9):1349-1364, 2018 Sep.
Abstract: Current guidelines recommend that percutaneous coronary intervention (PCI) should be restricted to the culprit vessel in ST elevation myocardial infarction (STEMI) patients with multi-vessel disease (MVD) and without cardiogenic shock. However, newer data suggests that performing complete revascularization (CR) in MVD patients may lead to better outcomes compared to intervention in the culprit vessel only. The aim of this meta-analysis is to examine the available data to determine if CR (using either angio- or fractional flow reserve guidance-FFR) following primary PCI in STEMI patients without cardiogenic shock impacts clinical outcomes. Meta-analysis was performed by conducting a literature search of PubMed from January 2004 to July 2017. Pooled estimates of outcomes, presented as odds ratios (OR) [95% confidence intervals], were generated using random-effect models. A total of 9 studies (3317 patients) were included. CR showed a significant MACE reduction (OR 0.49, 95% CI 0.36-0.66, p<0.001); All-cause mortality (OR 0.69, 95% CI 0.48-0.98, p=0.04) and repeat revascularization (OR 0.38, 95% CI 0.28-0.51, p<0.001) at>=12 months follow-up. The FFR-guiding CR group presented a MACE reduction (odds ratio 0.52, 95% CI 0.30-0.90, p=0.02) due to a decrease of repeat revascularization (OR 0.41, 95% CI 0.21-0.80, p=0.009). Overall, performing complete revascularization in STEMI patients showed a MACE reduction, all-cause death and repeat revascularization. Compared to culprit-only revascularization, treating multi-vessel disease in STEMI patients using FFR guidance is associated with decreased incidence of MACE, due to a decreased rate of revascularization.