Recommendations for Screening and Diagnosis of Chagas Disease in the United States.

MedStar author(s):
Citation: Journal of Infectious Diseases. 225(9):1601-1610, 2022 05 04.PMID: 34623435Institution: MedStar Heart & Vascular InstituteForm of publication: Journal ArticleMedline article type(s): Journal Article | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, P.H.S.Subject headings: *Chagas Disease | *Trypanosoma cruzi | Chagas Disease/di [Diagnosis] | Chagas Disease/ep [Epidemiology] | Female | Humans | Infant | Infectious Disease Transmission, Vertical/pc [Prevention & Control] | Mass Screening | Mothers | United States/ep [Epidemiology]Year: 2022Local holdings: Available online from MWHC library: April 1997 - present, Available in print through MWHC library: 1999 - presentISSN:
  • 0022-1899
Name of journal: The Journal of infectious diseasesAbstract: BACKGROUND: Chagas disease affects an estimated 326 000-347 000 people in the United States and is severely underdiagnosed. Lack of awareness and clarity regarding screening and diagnosis is a key barrier. This article provides straightforward recommendations, with the goal of simplifying identification and testing of people at risk for US healthcare providers.CONCLUSIONS: Increasing provider-directed screening for T. cruzi infection is key to addressing this neglected public health challenge in the United States. Copyright © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.METHODS: A multidisciplinary working group of clinicians and researchers with expertise in Chagas disease agreed on 6 main questions, and developed recommendations based on the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology, after reviewing the relevant literature on Chagas disease in the United States.RESULTS: Individuals who were born or resided for prolonged time periods in endemic countries of Mexico and Central and South America should be tested for Trypanosoma cruzi infection, and family members of people who test positive should be screened. Women of childbearing age with risk factors and infants born to seropositive mothers deserve special consideration due to the risk of vertical transmission. Diagnostic testing for chronic T. cruzi infection should be conducted using 2 distinct assays.All authors: Beatty NL, Bern C, Castro-Sesquen YE, Coyle C, Edwards M, Forsyth CJ, Gilman RH, Hamer D, Hochberg NS, Maguire JH, Manne-Goehler J, Marcus R, Meymandi S, Stigler Granados P, Whitman JFiscal year: FY2022Digital Object Identifier: Date added to catalog: 2022-07-06
Holdings
Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 34623435 Available 34623435

Available online from MWHC library: April 1997 - present, Available in print through MWHC library: 1999 - present

BACKGROUND: Chagas disease affects an estimated 326 000-347 000 people in the United States and is severely underdiagnosed. Lack of awareness and clarity regarding screening and diagnosis is a key barrier. This article provides straightforward recommendations, with the goal of simplifying identification and testing of people at risk for US healthcare providers.

CONCLUSIONS: Increasing provider-directed screening for T. cruzi infection is key to addressing this neglected public health challenge in the United States. Copyright © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.

METHODS: A multidisciplinary working group of clinicians and researchers with expertise in Chagas disease agreed on 6 main questions, and developed recommendations based on the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology, after reviewing the relevant literature on Chagas disease in the United States.

RESULTS: Individuals who were born or resided for prolonged time periods in endemic countries of Mexico and Central and South America should be tested for Trypanosoma cruzi infection, and family members of people who test positive should be screened. Women of childbearing age with risk factors and infants born to seropositive mothers deserve special consideration due to the risk of vertical transmission. Diagnostic testing for chronic T. cruzi infection should be conducted using 2 distinct assays.

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