Supporting evidence from optical coherence tomography for shortening dual antiplatelet therapy after drug-eluting stents implantation. [Review]

MedStar author(s):
Citation: Expert Review of Cardiovascular Therapy. 18(5):261-267, 2020 May.PMID: 32321328Institution: MedStar Heart & Vascular InstituteForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Drug-Eluting Stents | *Platelet Aggregation Inhibitors/ad [Administration & Dosage] | *Tomography, Optical Coherence/mt [Methods] | Coronary Artery Disease/th [Therapy] | Hemorrhage/ci [Chemically Induced] | Humans | Neointima | Thrombosis/et [Etiology] | Treatment OutcomeYear: 2020ISSN:
  • 1477-9072
Name of journal: Expert review of cardiovascular therapyAbstract: Introduction: Dual antiplatelet therapy (DAPT) is required for coronary artery disease treated with drug-eluting stents (DES) implantation. Shortening DAPT duration would be beneficial for patients with high bleeding risk. Areas covered: Early healing patterns, especially stent strut coverage, assessed by optical coherence tomography (OCT) as a surrogate of neointima have been investigated to make decisions on whether short DAPT would be a safe alternative. This review evaluates the OCT evidence (i.e. neointimal coverage of stent struts within 3 months) for shortening DAPT duration after DES implantation. Expert commentary: Shortening DAPT (i.e. within 3 months) duration after DES implantation might reduce complications including bleeding without increasing stent thrombosis. However, the optimal duration of DAPT after DES implantation is under discussion. Long-term assessment of short DAPT is required for the decision of the new guidelines regarding the recommended duration of DAPT.All authors: Garcia-Garcia HM, Mintz GS, Ozaki Y, Waksman ROriginally published: Expert Review of Cardiovascular Therapy. :1-7, 2020 May 04Fiscal year: FY2020Digital Object Identifier: Date added to catalog: 2020-07-09
Holdings
Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 32321328 Available 32321328

Introduction: Dual antiplatelet therapy (DAPT) is required for coronary artery disease treated with drug-eluting stents (DES) implantation. Shortening DAPT duration would be beneficial for patients with high bleeding risk. Areas covered: Early healing patterns, especially stent strut coverage, assessed by optical coherence tomography (OCT) as a surrogate of neointima have been investigated to make decisions on whether short DAPT would be a safe alternative. This review evaluates the OCT evidence (i.e. neointimal coverage of stent struts within 3 months) for shortening DAPT duration after DES implantation. Expert commentary: Shortening DAPT (i.e. within 3 months) duration after DES implantation might reduce complications including bleeding without increasing stent thrombosis. However, the optimal duration of DAPT after DES implantation is under discussion. Long-term assessment of short DAPT is required for the decision of the new guidelines regarding the recommended duration of DAPT.

English

Powered by Koha