Supporting evidence from optical coherence tomography for shortening dual antiplatelet therapy after drug-eluting stents implantation. [Review]
Citation: Expert Review of Cardiovascular Therapy. 18(5):261-267, 2020 May.PMID: 32321328Institution: MedStar Heart & Vascular InstituteForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Drug-Eluting Stents | *Platelet Aggregation Inhibitors/ad [Administration & Dosage] | *Tomography, Optical Coherence/mt [Methods] | Coronary Artery Disease/th [Therapy] | Hemorrhage/ci [Chemically Induced] | Humans | Neointima | Thrombosis/et [Etiology] | Treatment OutcomeYear: 2020ISSN:- 1477-9072
Item type | Current library | Collection | Call number | Status | Date due | Barcode |
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Journal Article | MedStar Authors Catalog | Article | 32321328 | Available | 32321328 |
Introduction: Dual antiplatelet therapy (DAPT) is required for coronary artery disease treated with drug-eluting stents (DES) implantation. Shortening DAPT duration would be beneficial for patients with high bleeding risk. Areas covered: Early healing patterns, especially stent strut coverage, assessed by optical coherence tomography (OCT) as a surrogate of neointima have been investigated to make decisions on whether short DAPT would be a safe alternative. This review evaluates the OCT evidence (i.e. neointimal coverage of stent struts within 3 months) for shortening DAPT duration after DES implantation. Expert commentary: Shortening DAPT (i.e. within 3 months) duration after DES implantation might reduce complications including bleeding without increasing stent thrombosis. However, the optimal duration of DAPT after DES implantation is under discussion. Long-term assessment of short DAPT is required for the decision of the new guidelines regarding the recommended duration of DAPT.
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