Normal view MARC view ISBD view

Clinical features of hypertriglyceridemia-induced acute pancreatitis in an international, multicenter, prospective cohort (APPRENTICE consortium).

MedStar author(s):

1424-3903

Name of journal: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]Abstract: BACKGROUND: The clinical features and outcomes of hypertriglyceridemia-induced acute pancreatitis (HTG-AP) are not well-established.CONCLUSION: HTG-AP was found to be the 4th most common etiology of AP. HTG-AP patients had distinct baseline characteristics, but their clinical outcomes were similar compared to other etiologies of AP. Copyright (c) 2020 IAP and EPC. Published by Elsevier B.V. All rights reserved.METHODS: Data collection was conducted prospectively through APPRENTICE between 2015 and 2018. HTG-AP was defined as serum TG levels >500 mg/dl in the absence of other common etiologies of AP. Three multivariate logistic regression models were performed to assess whether HTG-AP is associated with SIRS positive status, ICU admission and/or moderately-severe/severe AP.OBJECTIVE: To evaluate the clinical characteristics of HTG-AP in an international, multicenter prospective cohort.RESULTS: 1,478 patients were included in the study; 69 subjects (4.7%) were diagnosed with HTG-AP. HTG-AP patients were more likely to be younger (mean 40 vs 50 years; p < 0.001), male (67% vs 52%; p = 0.018), and with a higher BMI (mean 30.4 vs 27.5 kg/m2; p = 0.0002). HTG-AP subjects reported more frequent active alcohol use (71% vs 49%; p < 0.001), and diabetes mellitus (59% vs 15%; p < 0.001). None of the above risk factors/variables was found to be independently associated with SIRS positive status, ICU admission, or severity in the multivariate logistic regression models. These results were similar when including only the 785 subjects with TG levels measured within 48 h from admission.All authors: Archibugi L, Barbu ST, Capurso G, Cote GA, de-Madaria E, Easler J, Ferreira M, Goenka MK, Gonzalez JA, Gulla A, Gutierrez SC, Kochhar R, Nawaz H, Ocampo C, Papachristou GI, Paragomi P, Pelaez-Luna M, Pothoulakis I, Singh VK, Stevens T, Talukdar R, Tang G, Thakkar S, Triantafyllou K, Tuft M, Wu BU, Zarnescu NOOriginally published: Pancreatology. 20(3):325-330, 2020 Apr.Fiscal year: FY2020Digital Object Identifier:

https://dx.doi.org/10.1016/j.pan.2020.02.010

Date added to catalog: 2020-07-09

Holdings ( 1 )
Title notes ( 6 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	32107193	Available		32107193

BACKGROUND: The clinical features and outcomes of hypertriglyceridemia-induced acute pancreatitis (HTG-AP) are not well-established.

CONCLUSION: HTG-AP was found to be the 4th most common etiology of AP. HTG-AP patients had distinct baseline characteristics, but their clinical outcomes were similar compared to other etiologies of AP. Copyright (c) 2020 IAP and EPC. Published by Elsevier B.V. All rights reserved.

METHODS: Data collection was conducted prospectively through APPRENTICE between 2015 and 2018. HTG-AP was defined as serum TG levels >500 mg/dl in the absence of other common etiologies of AP. Three multivariate logistic regression models were performed to assess whether HTG-AP is associated with SIRS positive status, ICU admission and/or moderately-severe/severe AP.

OBJECTIVE: To evaluate the clinical characteristics of HTG-AP in an international, multicenter prospective cohort.

RESULTS: 1,478 patients were included in the study; 69 subjects (4.7%) were diagnosed with HTG-AP. HTG-AP patients were more likely to be younger (mean 40 vs 50 years; p < 0.001), male (67% vs 52%; p = 0.018), and with a higher BMI (mean 30.4 vs 27.5 kg/m2; p = 0.0002). HTG-AP subjects reported more frequent active alcohol use (71% vs 49%; p < 0.001), and diabetes mellitus (59% vs 15%; p < 0.001). None of the above risk factors/variables was found to be independently associated with SIRS positive status, ICU admission, or severity in the multivariate logistic regression models. These results were similar when including only the 785 subjects with TG levels measured within 48 h from admission.

English