Citation: Eurointervention. 9(8):979-88, 2013 Dec..Journal: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.ISSN: 1774-024X.Full author list: Loh JP; Barbash IM; Waksman R.UI/PMID: 24384294.Subject(s): Angioplasty, Balloon, Coronary/mt [Methods] | Animals | *Clinical Trials as Topic | *Coronary Artery Disease/th [Therapy] | Coronary Restenosis/th [Therapy] | *Drug-Eluting Stents | Humans | *Percutaneous Coronary InterventionInstitution(s): MedStar Heart & Vascular InstituteActivity type: Journal Article.Medline article type(s): Journal Article | ReviewDigital Object Identifier: http://dx.doi.org/10.4244/EIJV9I8A164 (Click here)Abbreviated citation: EuroIntervention. 9(8):979-88, 2013 Dec.Abstract: Through continued innovation, percutaneous treatment of coronary and peripheral stenoses has evolved rapidly since balloon angioplasty was first introduced three decades ago. Significant advances were made with the introduction of bare metal stents and subsequently drug-eluting stents, which expanded the possibility of successful revascularisation in complicated lesions. Despite these advantages, efforts are still ongoing to improve patient outcomes further. In recent years, drug-coated balloons have emerged as an exciting technology developed to overcome the limitations faced by drug-eluting stents, such as stent thrombosis and dependency on prolonged dual antiplatelet therapy, and may prove efficacious in complex subsets such as small vessels and diffuse lesions where stent results are suboptimal. Several drug-coated balloons developed for coronary and peripheral applications were evaluated recently in preclinical and clinical studies with encouraging results. Drug-coated balloons have proven effective in treating in-stent restenosis; however, there is accumulating evidence on their utility in other clinical scenarios. We present a timely review of the mechanisms of action, key preclinical studies, emerging clinical indications, current clinical trial results, and future perspectives of this novel drug-coated balloon technology as it seeks to establish its role in percutaneous intervention.