Natural History of Adapted Leaman Score Assessing Coronary Artery Disease Progression by Computed Tomography Angiography: A 7-Year Follow-Up Report.

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Citation: Cardiovascular Revascularization Medicine. 27:38-44, 2021 06.PMID: 33097462Institution: MedStar Heart & Vascular Institute | MedStar Washington Hospital CenterForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Coronary Artery Disease | *Coronary Stenosis | *Plaque, Atherosclerotic | Computed Tomography Angiography | Coronary Angiography | Coronary Artery Disease/dg [Diagnostic Imaging] | Follow-Up Studies | Humans | Predictive Value of Tests | Risk Assessment | Tomography, X-Ray ComputedYear: 2021Local holdings: Available in print through MWHC library: 2002 - presentISSN:
  • 1878-0938
Name of journal: Cardiovascular revascularization medicine : including molecular interventionsAbstract: BACKGROUND: Coronary computed tomographic angiography (CCTA) provides a non-invasive assessment of the coronary artery tree. Computed Tomography - adapted Leaman Score (CT-LeSc) has been shown to be an independent predictor of cardiac events in coronary artery disease (CAD) patients with a score greater than 5 (high).CONCLUSION: In patients at high-risk for cardiac events, as determined by CT-LeSc, there was an increase in CT-LeSc, obstructive lesions, and calcified plaques over the 7-year follow-up period. Most of the new lesions were obstructive and non-calcified. This is the first report showing long term serial imaging CCTA changes in a high-risk population. Copyright (c) 2020 Elsevier Inc. All rights reserved.METHODS: Patients with multivessel CAD and CCTA assessments at baseline and follow-up were included. The CT-LeSc analysis was performed in a paired fashion. The patient-level scores and the differences between each phase were assessed by 2 analysts in an independent CoreLab.PURPOSE: To investigate the relationship between CT-LeSc and the progression of CAD and to provide vessel- and segment-level CAD qualification and quantification at baseline and 7-year follow-up.RESULTS: This study analyzed 248 coronary segments from 17 patients with a mean follow-up interval of 7.5 +/- 0.6 years. The mean CT-LeSc at baseline and follow-up were 14.6 +/- 4.2 and 16.9 +/- 1.5, respectively, with an absolute increase of 2.3 +/- 1.8. The mean cumulative increase of new lesions was 0.2 +/- 0.2 per year. Over time, 14.6% of the non-obstructive lesions became obstructive, and 15.0% of the non-calcified plaques became calcified. There were 29 new lesions found at follow-up, and out of these, 16 were obstructive and 19 were non-calcified.All authors: Bittencourt M, Cavalcante R, Dan K, Falcao BAA, Falcao JLA, Freire AFD, Garcia-Garcia HM, Hideo-Kajita A, Lemos PA, Ozaki Y, Pinheiro TL, Ribeiro E, Rochitte CE, Rubarth R, Soares P, Wopperer SOriginally published: Cardiovascular Revascularization Medicine. 2020 Jul 26Fiscal year: FY2021Fiscal year of original publication: FY2021Digital Object Identifier: Date added to catalog: 2020-12-29
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Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 33097462 Available 33097462

Available in print through MWHC library: 2002 - present

BACKGROUND: Coronary computed tomographic angiography (CCTA) provides a non-invasive assessment of the coronary artery tree. Computed Tomography - adapted Leaman Score (CT-LeSc) has been shown to be an independent predictor of cardiac events in coronary artery disease (CAD) patients with a score greater than 5 (high).

CONCLUSION: In patients at high-risk for cardiac events, as determined by CT-LeSc, there was an increase in CT-LeSc, obstructive lesions, and calcified plaques over the 7-year follow-up period. Most of the new lesions were obstructive and non-calcified. This is the first report showing long term serial imaging CCTA changes in a high-risk population. Copyright (c) 2020 Elsevier Inc. All rights reserved.

METHODS: Patients with multivessel CAD and CCTA assessments at baseline and follow-up were included. The CT-LeSc analysis was performed in a paired fashion. The patient-level scores and the differences between each phase were assessed by 2 analysts in an independent CoreLab.

PURPOSE: To investigate the relationship between CT-LeSc and the progression of CAD and to provide vessel- and segment-level CAD qualification and quantification at baseline and 7-year follow-up.

RESULTS: This study analyzed 248 coronary segments from 17 patients with a mean follow-up interval of 7.5 +/- 0.6 years. The mean CT-LeSc at baseline and follow-up were 14.6 +/- 4.2 and 16.9 +/- 1.5, respectively, with an absolute increase of 2.3 +/- 1.8. The mean cumulative increase of new lesions was 0.2 +/- 0.2 per year. Over time, 14.6% of the non-obstructive lesions became obstructive, and 15.0% of the non-calcified plaques became calcified. There were 29 new lesions found at follow-up, and out of these, 16 were obstructive and 19 were non-calcified.

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