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High level of selenium exposure in the Strong Heart Study: a cause for incident cardiovascular disease?.

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Citation: Antioxidants & Redox Signaling. 2022 Mar 30PMID: 35350849Institution: MedStar Health Research InstituteForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: IN PROCESS -- NOT YET INDEXEDYear: 2022 ISSN:

1523-0864

Name of journal: Antioxidants & redox signalingAbstract: Increasing evidence suggests that high selenium (Se) exposure is associated with adverse health effects. However, limited evidence exists on the association of Se exposure with cardiovascular disease (CVD), especially in communities affected by high naturally occurring Se in environmental media. We evaluated the prospective association between urinary Se levels and CVD incidence and mortality for 2,727 American Indian adults who participated in the Strong Heart Study, with urinary Se levels measured at baseline (1989-1991) and CVD outcomes ascertained through 2017. The median (interquartile range) of urinary Se was 49.0 (36.7, 67.4) microg/g creatinine. The multivariable adjusted hazard ratios (95%CI) of incident CVD, coronary heart disease, and stroke comparing the 75th vs. 25th percentile of urinary Se distributions were 1.11 (1.01, 1.22), 1.05 (0.94, 1.17), and 1.08 (0.88, 1.33), respectively. In flexible dose-response models, increased risk for CVD incidence was only observed when urinary Se level exceeded 60 microg/g creatinine. For CVD mortality, a non-statistically significant U-shaped relationship was found across urinary Se levels. There was no evidence of effect modification by other urinary metal/metalloid levels. Our observation leads to the hypothesis that elevated Se exposure is a risk factor for CVD, especially in Se-replete populations.All authors: Ali T, Best LG, Cole SA, Domingo-Relloso A, Fretts A, Goessler W, Moon KA, Navas-Acien A, Nigra AE, Tellez-Plaza M, Umans JG, Valeri L, Zhao DFiscal year: FY2022 Digital Object Identifier:

https://dx.doi.org/10.1089/ars.2022.0029

Date added to catalog: 2022-05-11

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Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	35350849	Available		35350849

Increasing evidence suggests that high selenium (Se) exposure is associated with adverse health effects. However, limited evidence exists on the association of Se exposure with cardiovascular disease (CVD), especially in communities affected by high naturally occurring Se in environmental media. We evaluated the prospective association between urinary Se levels and CVD incidence and mortality for 2,727 American Indian adults who participated in the Strong Heart Study, with urinary Se levels measured at baseline (1989-1991) and CVD outcomes ascertained through 2017. The median (interquartile range) of urinary Se was 49.0 (36.7, 67.4) microg/g creatinine. The multivariable adjusted hazard ratios (95%CI) of incident CVD, coronary heart disease, and stroke comparing the 75th vs. 25th percentile of urinary Se distributions were 1.11 (1.01, 1.22), 1.05 (0.94, 1.17), and 1.08 (0.88, 1.33), respectively. In flexible dose-response models, increased risk for CVD incidence was only observed when urinary Se level exceeded 60 microg/g creatinine. For CVD mortality, a non-statistically significant U-shaped relationship was found across urinary Se levels. There was no evidence of effect modification by other urinary metal/metalloid levels. Our observation leads to the hypothesis that elevated Se exposure is a risk factor for CVD, especially in Se-replete populations.

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