MedStar Authors catalog › Details for: Clinical effects of reported synthetic cannabinoid exposure in patients admitted to the intensive care unit.
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Clinical effects of reported synthetic cannabinoid exposure in patients admitted to the intensive care unit.

by Goyal, Munish; Mazer-Amirshahi, Maryann; Tatusov, Michael.
Citation: American Journal of Emergency Medicine. 37(6):1060-1064, 2019 Jun..Journal: The American journal of emergency medicine.Published: 2019; ; ; ISSN: 0735-6757.Full author list: Abbasi A; Goyal M; Mazer-Amirshahi M; Tatusov M.UI/PMID: 30146395.Subject(s): *Cannabinoids/ae [Adverse Effects] | *Synthetic Drugs/ae [Adverse Effects] | Adult | Female | Hospitalization/sn [Statistics & Numerical Data] | Humans | Intensive Care Units/og [Organization & Administration] | Intensive Care Units/sn [Statistics & Numerical Data] | Length of Stay/sn [Statistics & Numerical Data] | Male | Middle Aged | Pulmonary Edema/et [Etiology] | Retrospective Studies | Severity of Illness Index | Tachycardia/et [Etiology]Institution(s): MedStar Washington Hospital CenterDepartment(s): Emergency Medicine | Medicine/Pulmonary-Critical CareActivity type: Journal Article.Medline article type(s): Journal ArticleOnline resources: Click here to access online Digital Object Identifier: https://dx.doi.org/10.1016/j.ajem.2018.08.048 (Click here) Abbreviated citation: Am J Emerg Med. 37(6):1060-1064, 2019 Jun.Local Holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006.Abstract: CONCLUSIONS: Patients admitted to ICU after SC exposure exhibit significant organ dysfunction, particularly neurologic and respiratory. Prognosis is good with supportive care.Abstract: Copyright (c) 2018. Published by Elsevier Inc.Abstract: DESIGN: Retrospective case series of patients admitted to medical or cardiac ICU.Abstract: MEASUREMENTS: Demographics, Sequential Organ Failure Assessment (SOFA) scores, and clinical parameters documenting the effects and hospital course.Abstract: OBJECTIVE: To characterize the clinical presentation and hospital course of patients with reported synthetic cannabinoid (SC) exposure requiring Intensive Care Unit (ICU) admission.Abstract: PARTICIPANTS: Adults >=18years old admitted from the emergency department (ED) in 2015.Abstract: RESULTS: 23 patients met inclusion criteria. Median age was 47years (interquartile range [IQR], 32-54); 83% male; 78% black. Patients were generally tachycardic (HR>100), (65%) and hypertensive (SBP>140), (65%) on admission. The initial chest X-ray and ECG were abnormal in 43% and 68% of patients, respectively. Pulmonary edema and tachycardia were the most common findings. Head CT imaging was abnormal in 5% of patients. Troponin was elevated >1.0ng/ml in 3 of 19 patients (16%). Other exposures detected on admission were marijuana (30%), alcohol (30%), and benzodiazepines (26%). The median SOFA score was 6 on admission and decreased over the next 3days. SOFA scores were primarily driven by altered neurologic status and respiratory failure. 91% required mechanical ventilation, 30% had seizures as a part of presentation, 18% required vasopressors, and 5% needed dialysis. Median hospital and ICU lengths of stay were 2.6 (IQR 1.4-3.5) and 1.6 (IQR 0.9-2.5) days, respectively. The median hospital charge was Abstract: SETTING: Urban tertiary care center.

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